Genetic factors influence serological measures of common infections

Rohina Rubicz, Charles T. Leach, Ellen B Kraig, Nikhil V. Dhurandhar, Ravindranath Duggirala, John Blangero, Robert Yolken, Harald H H Göring

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    Background/Aims: Antibodies against infectious pathogens provide information on past or present exposure to infectious agents. While host genetic factors are known to affect the immune response, the influence of genetic factors on antibody levels to common infectious agents is largely unknown. Here we test whether antibody levels for 13 common infections are significantly heritable. Methods: IgG antibodies to Chlamydophila pneumoniae, Helicobacter pylori, Toxoplasma gondii, adenovirus 36 (Ad36), hepatitis A virus, influenza A and B, cytomegalovirus, Epstein-Barr virus, herpes simplex virus (HSV)-1 and-2, human herpesvirus-6, and varicella zoster virus were determined for 1,227 Mexican Americans. Both quantitative and dichotomous (seropositive/seronegative) traits were analyzed. Influences of genetic and shared environmental factors were estimated using variance components pedigree analysis, and sharing of underlying genetic factors among traits was investigated using bivariate analyses. Results: Serological phenotypes were significantly heritable for most pathogens (h 2 = 0.17-0.39), except for Ad36 and HSV-2. Shared environment was significant for several pathogens (c 2 = 0.10-0.32). The underlying genetic etiology appears to be largely different for most pathogens. Conclusions: Our results demonstrate, for the first time for many of these pathogens, that individual genetic differences of the human host contribute substantially to antibody levels to many common infectious agents, providing impetus for the identification of underlying genetic variants, which may be of clinical importance.

    Original languageEnglish (US)
    Pages (from-to)133-141
    Number of pages9
    JournalHuman Heredity
    Volume72
    Issue number2
    DOIs
    StatePublished - Oct 2011

    Fingerprint

    Antibodies
    Infection
    Human Herpesvirus 2
    Adenoviridae
    Human Herpesvirus 6
    Hepatitis A virus
    Chlamydophila pneumoniae
    Human Herpesvirus 3
    Toxoplasma
    Medical Genetics
    Human Herpesvirus 1
    Pedigree
    Cytomegalovirus
    Human Herpesvirus 4
    Individuality
    Helicobacter pylori
    Human Influenza
    Immunoglobulin G
    Phenotype

    Keywords

    • Antibody
    • Genetics
    • Heritability
    • Infection
    • Mexican Americans
    • Pathogen
    • Serology

    ASJC Scopus subject areas

    • Genetics(clinical)
    • Genetics

    Cite this

    Rubicz, R., Leach, C. T., Kraig, E. B., Dhurandhar, N. V., Duggirala, R., Blangero, J., ... Göring, H. H. H. (2011). Genetic factors influence serological measures of common infections. Human Heredity, 72(2), 133-141. https://doi.org/10.1159/000331220

    Genetic factors influence serological measures of common infections. / Rubicz, Rohina; Leach, Charles T.; Kraig, Ellen B; Dhurandhar, Nikhil V.; Duggirala, Ravindranath; Blangero, John; Yolken, Robert; Göring, Harald H H.

    In: Human Heredity, Vol. 72, No. 2, 10.2011, p. 133-141.

    Research output: Contribution to journalArticle

    Rubicz, R, Leach, CT, Kraig, EB, Dhurandhar, NV, Duggirala, R, Blangero, J, Yolken, R & Göring, HHH 2011, 'Genetic factors influence serological measures of common infections', Human Heredity, vol. 72, no. 2, pp. 133-141. https://doi.org/10.1159/000331220
    Rubicz R, Leach CT, Kraig EB, Dhurandhar NV, Duggirala R, Blangero J et al. Genetic factors influence serological measures of common infections. Human Heredity. 2011 Oct;72(2):133-141. https://doi.org/10.1159/000331220
    Rubicz, Rohina ; Leach, Charles T. ; Kraig, Ellen B ; Dhurandhar, Nikhil V. ; Duggirala, Ravindranath ; Blangero, John ; Yolken, Robert ; Göring, Harald H H. / Genetic factors influence serological measures of common infections. In: Human Heredity. 2011 ; Vol. 72, No. 2. pp. 133-141.
    @article{2c56a8854706433e94a02bc8ff2b5e74,
    title = "Genetic factors influence serological measures of common infections",
    abstract = "Background/Aims: Antibodies against infectious pathogens provide information on past or present exposure to infectious agents. While host genetic factors are known to affect the immune response, the influence of genetic factors on antibody levels to common infectious agents is largely unknown. Here we test whether antibody levels for 13 common infections are significantly heritable. Methods: IgG antibodies to Chlamydophila pneumoniae, Helicobacter pylori, Toxoplasma gondii, adenovirus 36 (Ad36), hepatitis A virus, influenza A and B, cytomegalovirus, Epstein-Barr virus, herpes simplex virus (HSV)-1 and-2, human herpesvirus-6, and varicella zoster virus were determined for 1,227 Mexican Americans. Both quantitative and dichotomous (seropositive/seronegative) traits were analyzed. Influences of genetic and shared environmental factors were estimated using variance components pedigree analysis, and sharing of underlying genetic factors among traits was investigated using bivariate analyses. Results: Serological phenotypes were significantly heritable for most pathogens (h 2 = 0.17-0.39), except for Ad36 and HSV-2. Shared environment was significant for several pathogens (c 2 = 0.10-0.32). The underlying genetic etiology appears to be largely different for most pathogens. Conclusions: Our results demonstrate, for the first time for many of these pathogens, that individual genetic differences of the human host contribute substantially to antibody levels to many common infectious agents, providing impetus for the identification of underlying genetic variants, which may be of clinical importance.",
    keywords = "Antibody, Genetics, Heritability, Infection, Mexican Americans, Pathogen, Serology",
    author = "Rohina Rubicz and Leach, {Charles T.} and Kraig, {Ellen B} and Dhurandhar, {Nikhil V.} and Ravindranath Duggirala and John Blangero and Robert Yolken and G{\"o}ring, {Harald H H}",
    year = "2011",
    month = "10",
    doi = "10.1159/000331220",
    language = "English (US)",
    volume = "72",
    pages = "133--141",
    journal = "Human Heredity",
    issn = "0001-5652",
    publisher = "S. Karger AG",
    number = "2",

    }

    TY - JOUR

    T1 - Genetic factors influence serological measures of common infections

    AU - Rubicz, Rohina

    AU - Leach, Charles T.

    AU - Kraig, Ellen B

    AU - Dhurandhar, Nikhil V.

    AU - Duggirala, Ravindranath

    AU - Blangero, John

    AU - Yolken, Robert

    AU - Göring, Harald H H

    PY - 2011/10

    Y1 - 2011/10

    N2 - Background/Aims: Antibodies against infectious pathogens provide information on past or present exposure to infectious agents. While host genetic factors are known to affect the immune response, the influence of genetic factors on antibody levels to common infectious agents is largely unknown. Here we test whether antibody levels for 13 common infections are significantly heritable. Methods: IgG antibodies to Chlamydophila pneumoniae, Helicobacter pylori, Toxoplasma gondii, adenovirus 36 (Ad36), hepatitis A virus, influenza A and B, cytomegalovirus, Epstein-Barr virus, herpes simplex virus (HSV)-1 and-2, human herpesvirus-6, and varicella zoster virus were determined for 1,227 Mexican Americans. Both quantitative and dichotomous (seropositive/seronegative) traits were analyzed. Influences of genetic and shared environmental factors were estimated using variance components pedigree analysis, and sharing of underlying genetic factors among traits was investigated using bivariate analyses. Results: Serological phenotypes were significantly heritable for most pathogens (h 2 = 0.17-0.39), except for Ad36 and HSV-2. Shared environment was significant for several pathogens (c 2 = 0.10-0.32). The underlying genetic etiology appears to be largely different for most pathogens. Conclusions: Our results demonstrate, for the first time for many of these pathogens, that individual genetic differences of the human host contribute substantially to antibody levels to many common infectious agents, providing impetus for the identification of underlying genetic variants, which may be of clinical importance.

    AB - Background/Aims: Antibodies against infectious pathogens provide information on past or present exposure to infectious agents. While host genetic factors are known to affect the immune response, the influence of genetic factors on antibody levels to common infectious agents is largely unknown. Here we test whether antibody levels for 13 common infections are significantly heritable. Methods: IgG antibodies to Chlamydophila pneumoniae, Helicobacter pylori, Toxoplasma gondii, adenovirus 36 (Ad36), hepatitis A virus, influenza A and B, cytomegalovirus, Epstein-Barr virus, herpes simplex virus (HSV)-1 and-2, human herpesvirus-6, and varicella zoster virus were determined for 1,227 Mexican Americans. Both quantitative and dichotomous (seropositive/seronegative) traits were analyzed. Influences of genetic and shared environmental factors were estimated using variance components pedigree analysis, and sharing of underlying genetic factors among traits was investigated using bivariate analyses. Results: Serological phenotypes were significantly heritable for most pathogens (h 2 = 0.17-0.39), except for Ad36 and HSV-2. Shared environment was significant for several pathogens (c 2 = 0.10-0.32). The underlying genetic etiology appears to be largely different for most pathogens. Conclusions: Our results demonstrate, for the first time for many of these pathogens, that individual genetic differences of the human host contribute substantially to antibody levels to many common infectious agents, providing impetus for the identification of underlying genetic variants, which may be of clinical importance.

    KW - Antibody

    KW - Genetics

    KW - Heritability

    KW - Infection

    KW - Mexican Americans

    KW - Pathogen

    KW - Serology

    UR - http://www.scopus.com/inward/record.url?scp=80053905358&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=80053905358&partnerID=8YFLogxK

    U2 - 10.1159/000331220

    DO - 10.1159/000331220

    M3 - Article

    VL - 72

    SP - 133

    EP - 141

    JO - Human Heredity

    JF - Human Heredity

    SN - 0001-5652

    IS - 2

    ER -