Genetic expression of complement factors and α1-acid glycoprotein by liver tissue during senescence

Mark S. Rutherford, Carla S. Baehler, Arlan Richardson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of age on several messenger RNAs coding for non-specific immune factors were determined in liver RNA isolated from 6-, 12-, 24-, 29- and 37-month-old male Fischer Rats. The levels of complement factors C3 and C4, complement protein factor B, and α1-acid glycoprotein were determined by dot blot hybridization using cDNA probes. All four mRNAs increased slightly between 6 and 29 months of age. Only the mRNAs coding for complement factors C3 and C4 decreased significantly after 29 months of age. In addition, Northern blot analysis of the RNA preparations showed that the size of the four mRNA species did not change with increasing age. There was no evidence for age-related changes in the post-transcriptional processing or degradation of the mRNA species coding for complement factors C3 and C4, complement protein factor B, and α1-acid glycoprotein.

Original languageEnglish (US)
Pages (from-to)245-254
Number of pages10
JournalMechanisms of Ageing and Development
Volume35
Issue number3
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Complement C1
Complement C4
Liver
Complement C3
Glycoproteins
Tissue
Messenger RNA
Acids
Complement Factor B
RNA
Inbred F344 Rats
RNA Stability
Immunologic Factors
Northern Blotting
Complementary DNA
Rats
Degradation
Processing

Keywords

  • Complement C3
  • Complement C4
  • Complement protein factor B
  • Messenger RNA
  • Transcription
  • α-Acid glycoprotein

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Genetic expression of complement factors and α1-acid glycoprotein by liver tissue during senescence. / Rutherford, Mark S.; Baehler, Carla S.; Richardson, Arlan.

In: Mechanisms of Ageing and Development, Vol. 35, No. 3, 1986, p. 245-254.

Research output: Contribution to journalArticle

Rutherford, Mark S. ; Baehler, Carla S. ; Richardson, Arlan. / Genetic expression of complement factors and α1-acid glycoprotein by liver tissue during senescence. In: Mechanisms of Ageing and Development. 1986 ; Vol. 35, No. 3. pp. 245-254.
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