Genetic evaluation of the performance of malaria parasite clearance rate metrics

Standwell C. Nkhoma, Kasia Stepniewska, Shalini Nair, Aung Pyae Phyo, Rose McGready, François Nosten, Tim J.C. Anderson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Accurate measurement of malaria parasite clearance rates (CRs) following artemisinin (ART) treatment is critical for resistance surveillance and research, and various CR metrics are currently used. We measured 13 CR metrics in 1472 ART-treated hyperparasitemia infections for which 6-hour parasite counts and parasite genotypes (93 single nucleotide polymorphisms [SNPs]) were available. We used heritability to evaluate the performance of each metric. Heritability ranged from 0.06 ± 0.06 (SD) for 50% parasite clearance times to 0.67 ± 0.04 (SD) for clearance half-lives estimated from 6-hour parasite counts. These results identify the measures that should be avoided and show that reliable clearance measures can be obtained with abbreviated monitoring protocols.

Original languageEnglish (US)
Pages (from-to)346-350
Number of pages5
JournalJournal of Infectious Diseases
Volume208
Issue number2
DOIs
StatePublished - Jul 15 2013
Externally publishedYes

Keywords

  • Plasmodium falciparum
  • artemisinin
  • clearance rate
  • half-life
  • heritability
  • single nucleotide polymorphism

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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