Genetic epidemiology of non-insulin-dependent diabetes mellitus (NIDDM) in North India: Distribution of Gm and Km allotypes in 'Punjabis'

P. S. Gill, J. P. Pandey, J. Blangero, R. S. Corruccini, I. S. Gill

    Research output: Contribution to journalArticle

    4 Scopus citations

    Abstract

    Non-insulin dependent diabetes mellitus (NIDDM) is becoming endemic to modernizing and urbanizing populations all over the globe. The data on Gm and Km allotypes in the 'Punjabis' (n = 165) from North India show an interesting association with NIDDM. Differences between diabetic and control samples for the Km allele frequency distribution approach significance (P = 0.0897). The observed phenotypic diversity in the Gm system in diabetics indicates genetic heterogeneity in the disease group. A significant decrease (or absence) of phenotype Gm1,3,17; ;5,21 (P = 0.0119), and presence of phenotype Gm1,2,3,17; ;5,21 (P = 0.0158) in diabetics may constitute a risk factor for this disorder in 'Punjabis'.

    Original languageEnglish (US)
    Pages (from-to)59-67
    Number of pages9
    JournalDisease Markers
    Volume8
    Issue number2
    StatePublished - Jul 6 1990

    Keywords

    • Gm and Km allotypes
    • NIDDM
    • North India
    • Punjabis
    • genetic heterogeneity
    • haplotypes
    • phenotypes

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics
    • Clinical Biochemistry
    • Biochemistry, medical

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