Genetic differentiation between baboon subspecies

Relevance for biomedical research

S. Williams‐Blangero, J. L. Vandeberg, J. Blangero, L. Konigsberg, B. Dyke

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The use of common names which may encompass a number of subspecies or species is pervasive in the biomedical literature. Failure to identify the complete taxonomic classification of research subjects presents a source of error for scientists attempting to evaluate results or to repeat experiments. This paper examines the problem in a common animal model, the baboon. Analyses of the genetic distances among five baboon subspecies (Papio hamadryas anubis, P.h. cynocephalus, P.h. papio, P.h. ursinus, and P.h. hamadryas) based on blood marker information from nine polymorphic protein loci (ADA, APRT, C3, CA1, CA2, GPI, MPI, PEPB, and PGD) available for baboons resident at the Southwest Foundation for Biomedical Research are presented. Statistical tests on the distances showed that significant genetic differences exist among the subspecies. A comparison of P.h. anubis and P.h. cynocephalus revealed that these two subspecies also differ significantly for biomedically relevant lipoprotein cholesterol levels, as can be predicted from the genetic distances. The results emphasize the pitfalls of using different types of baboons interchangeably in experimental protocols.

Original languageEnglish (US)
Pages (from-to)67-81
Number of pages15
JournalAmerican Journal of Primatology
Volume20
Issue number2
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

biomedical research
Papio
genetic differentiation
subspecies
genetic variation
genetic distance
Papio ursinus
Papio hamadryas
common names
lipoproteins
statistical analysis
animal models
blood
cholesterol
calcium
loci
protein
animal
proteins
experiment

Keywords

  • isozymes
  • methods
  • Papio
  • population genetics
  • taxonomy

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Animal Science and Zoology

Cite this

Williams‐Blangero, S., Vandeberg, J. L., Blangero, J., Konigsberg, L., & Dyke, B. (1990). Genetic differentiation between baboon subspecies: Relevance for biomedical research. American Journal of Primatology, 20(2), 67-81. https://doi.org/10.1002/ajp.1350200202

Genetic differentiation between baboon subspecies : Relevance for biomedical research. / Williams‐Blangero, S.; Vandeberg, J. L.; Blangero, J.; Konigsberg, L.; Dyke, B.

In: American Journal of Primatology, Vol. 20, No. 2, 1990, p. 67-81.

Research output: Contribution to journalArticle

Williams‐Blangero, S, Vandeberg, JL, Blangero, J, Konigsberg, L & Dyke, B 1990, 'Genetic differentiation between baboon subspecies: Relevance for biomedical research', American Journal of Primatology, vol. 20, no. 2, pp. 67-81. https://doi.org/10.1002/ajp.1350200202
Williams‐Blangero, S. ; Vandeberg, J. L. ; Blangero, J. ; Konigsberg, L. ; Dyke, B. / Genetic differentiation between baboon subspecies : Relevance for biomedical research. In: American Journal of Primatology. 1990 ; Vol. 20, No. 2. pp. 67-81.
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