Genetic determination of biological age in the Mennonites of the Midwestern United States

Ravindranath Duggirala, Meredith Uttley, Ken Williams, Rector Arya, John Blangero, Michael H. Crawford

    Research output: Contribution to journalArticle

    9 Scopus citations

    Abstract

    Numerous studies have shown that longevity is moderately heritable in human populations. Longevity, however, contains limited information on functional status, since individuals may exhibit differential survival patterns. In this study, we employed a stepwise multiple regression approach to estimate biological aging in a Mennonite population, using chronological age as a dependent variable and various predictors of chronological age including subphenotypes related to diabetes, coronary heart disease, hypertension, renal function, and markers of functional ability. The residual (the difference between chronological and predicted ages) is considered a marker of biological age. In fact, two different data sets were used to obtain residuals due to the availability of data. In each analysis, chronological age was regressed on predictor variables in a stepwise manner, retaining the variables significant at the 5% level. The first analysis (N = 729) included 6 significant predictors (R2 = 44.3%): glucose, blood urea nitrogen (BUN), cholesterol, albumin, systolic blood pressure (SBP), and In potassium, and the second analysis (N = 232) included 9 significant predictors (R2 = 71.5%): BUN, albumin, SBP, low-density lipoprotein cholesterol, forced expiratory volume in 1 sec (FEV1), grip strength, trunk flexibility, reaction time, and FEV1 x sex. Using a variance components approach, we found that the data set-specific residuals were significantly heritable (h2±SE): first analysis =0.265±0.106, and second analysis =0.469±0.180. The residuals from the second data set appear to be more informative for biological aging, perhaps due to the inclusion of functional ability-related phenotypes in addition to the blood chemistry variables. In summary, we have shown that markers of biological aging in Mennonites are under substantial additive genetic influences.

    Original languageEnglish (US)
    Pages (from-to)97-109
    Number of pages13
    JournalGenetic epidemiology
    Volume23
    Issue number2
    DOIs
    StatePublished - Aug 2002

    Keywords

    • Aging
    • Genetics
    • Heritability
    • Pedigrees
    • Variance components

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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