Genetic determinants of risk factors for cardiovascular disease in a population from rural Brazil

Gustavo Velásquez-Meléndez, Flavia C. Parra, Andrea Gazzinelli, Sarah Williams-Blangero, Rodrigo Correa-Oliveira

    Research output: Contribution to journalArticle

    6 Scopus citations

    Abstract

    We investigate the heritability of and pleiotropic relationships among triglycerides and cholesterol lipoproteins that have long been considered traditional risk factors for cardiovascular disease. Quantitative lipid and lipoprotein phenotypes were determined for a cross-sectional sample of a community in Jequitinhonha valley in northern Minas Gerais state, Brazil. The sample consisted primarily of subsistence farmers. Two hundred sixty-nine individuals (128 males and 141 females), ages 18-88 years, were sampled. Eighty-eight percent (n = 252) of the individuals belonged to a single pedigree, which was highly informative for genetic analysis. Data on anthropometrics, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol, and triglycerides were available for each study participant. Extended pedigrees were constructed using the pedigree-based data management software PedSys. Univariate and bivariate variance-components analyses, adjusted by sex and age, were performed using the SOLAR software package. Heritability estimates of lipids and lipoproteins ranged from 29% to 45% (p < 0.008). The highest heritability estimated was for HDL-C (h2 = 44.8%, p < 0.0001), and this was the only trait that exhibited a significant household effect (c2 = 25%). Strong positive genetic correlations were found between triglycerides and very low density lipoprotein (VLDL) (ρg = 0.998) and between total cholesterol and LDL-C (ρg = 0.948). Significant genetic correlations were also found between triglycerides and LDL-C, between total cholesterol and VLDL, and between total cholesterol and LDL-C and VLDL, and finally between LDL and VLDL. There was a significant negative environmental correlation between triglycerides and HDL-C (ρe = -0.406).

    Original languageEnglish (US)
    Pages (from-to)179-190
    Number of pages12
    JournalHuman Biology
    Volume79
    Issue number2
    StatePublished - Apr 1 2007

    Keywords

    • Brazil
    • Cardiovascular disease
    • Genetics
    • Heritability
    • High-density lipoprotein cholesterol
    • Lipoproteins
    • Low-density lipoprotein cholesterol
    • Total cholesterol
    • Triglycerides

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Genetics
    • Genetics(clinical)

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  • Cite this

    Velásquez-Meléndez, G., Parra, F. C., Gazzinelli, A., Williams-Blangero, S., & Correa-Oliveira, R. (2007). Genetic determinants of risk factors for cardiovascular disease in a population from rural Brazil. Human Biology, 79(2), 179-190.