TY - JOUR
T1 - Genetic determinants of obesity-related lipid traits
AU - Sonnenberg, Gabriele E.
AU - Krakower, Glenn R.
AU - Martin, Lisa J.
AU - Olivier, Michael
AU - Kwitek, Anne E.
AU - Comuzzie, Anthony G.
AU - Blangero, John
AU - Kissebah, Ahmed H.
PY - 2004/4
Y1 - 2004/4
N2 - In our ongoing effort to identify genes influencing the biological pathways that underlie the metabolic disturbances associated with obesity, we performed genome-wide scanning in 2,209 individuals distributed over 507 Caucasian families to localize quantitative trait loci (QTLs), which affect variation of plasma lipids. Pedigree-based analysis using a quantitative trait variance component linkage method that localized a QTL on chromosome 7q35-q36, which linked to variation in levels of plasma triglyceride [TG, logarithm of odds (LOD) score = 3.7] and was suggestive of linkage to LDL-cholesterol (LDL-C, LOD = 2.2). Covariates of the TG linkage included waist circumference, fasting insulin, and insulin:glucose, but not body mass index or hip circumference. Plasma HDL-cholesterol (HDL-C) levels were suggestively linked to a second QTL on chromosome 12p12.3 (LOD = 2.6). Five other QTLs with lower LOD scores were identified for plasma levels of LDL-C, HDL-C, and total cholesterol. These newly identified loci likely harbor genetic elements that influence traits underlying lipid adversities associated with obesity.
AB - In our ongoing effort to identify genes influencing the biological pathways that underlie the metabolic disturbances associated with obesity, we performed genome-wide scanning in 2,209 individuals distributed over 507 Caucasian families to localize quantitative trait loci (QTLs), which affect variation of plasma lipids. Pedigree-based analysis using a quantitative trait variance component linkage method that localized a QTL on chromosome 7q35-q36, which linked to variation in levels of plasma triglyceride [TG, logarithm of odds (LOD) score = 3.7] and was suggestive of linkage to LDL-cholesterol (LDL-C, LOD = 2.2). Covariates of the TG linkage included waist circumference, fasting insulin, and insulin:glucose, but not body mass index or hip circumference. Plasma HDL-cholesterol (HDL-C) levels were suggestively linked to a second QTL on chromosome 12p12.3 (LOD = 2.6). Five other QTLs with lower LOD scores were identified for plasma levels of LDL-C, HDL-C, and total cholesterol. These newly identified loci likely harbor genetic elements that influence traits underlying lipid adversities associated with obesity.
KW - High density lipoprotein cholesterol
KW - Linkage analysis
KW - Lipid profiles
KW - Obesity
KW - Triglycerides
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U2 - 10.1194/jlr.M300474-JLR200
DO - 10.1194/jlr.M300474-JLR200
M3 - Article
C2 - 14754912
AN - SCOPUS:1642506267
VL - 45
SP - 610
EP - 615
JO - Journal of Lipid Research
JF - Journal of Lipid Research
SN - 0022-2275
IS - 4
ER -