Genetic determinants of obesity-related lipid traits

Gabriele E. Sonnenberg, Glenn R. Krakower, Lisa J. Martin, Michael Olivier, Anne E. Kwitek, Anthony G. Comuzzie, John Blangero, Ahmed H. Kissebah

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

In our ongoing effort to identify genes influencing the biological pathways that underlie the metabolic disturbances associated with obesity, we performed genome-wide scanning in 2,209 individuals distributed over 507 Caucasian families to localize quantitative trait loci (QTLs), which affect variation of plasma lipids. Pedigree-based analysis using a quantitative trait variance component linkage method that localized a QTL on chromosome 7q35-q36, which linked to variation in levels of plasma triglyceride [TG, logarithm of odds (LOD) score = 3.7] and was suggestive of linkage to LDL-cholesterol (LDL-C, LOD = 2.2). Covariates of the TG linkage included waist circumference, fasting insulin, and insulin:glucose, but not body mass index or hip circumference. Plasma HDL-cholesterol (HDL-C) levels were suggestively linked to a second QTL on chromosome 12p12.3 (LOD = 2.6). Five other QTLs with lower LOD scores were identified for plasma levels of LDL-C, HDL-C, and total cholesterol. These newly identified loci likely harbor genetic elements that influence traits underlying lipid adversities associated with obesity.

Original languageEnglish (US)
Pages (from-to)610-615
Number of pages6
JournalJournal of lipid research
Volume45
Issue number4
DOIs
StatePublished - Apr 2004
Externally publishedYes

Keywords

  • High density lipoprotein cholesterol
  • Linkage analysis
  • Lipid profiles
  • Obesity
  • Triglycerides

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

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