Genetic determinants of iron metabolism plasma phenotypes and their relationship with risk of thrombosis

Juan Carlos Souto, Angel Remacha, Alfonso Buil, Laura Almasyl, John Blangero, Jordi Fontcuberta

    Research output: Contribution to journalArticle

    4 Scopus citations

    Abstract

    This study evaluates the relative contributions of genetic and environmental factors to 6 iron-related phenotypes and the relationship between these phenotypes and the risk of thrombosis. All of these phenotypes were influenced significantly by genetics, with heritability ranging between 180% for transferrin saturation to 55% for soluble transferrin receptor (sTfR). Only sTfR exhibited a significant genetic correlation with thrombosis.

    Original languageEnglish (US)
    Pages (from-to)1436-1438
    Number of pages3
    JournalHaematologica
    Volume88
    Issue number12
    StatePublished - Dec 2003

    Keywords

    • Family studies
    • Genetics
    • Heritability
    • Iron metabolism
    • Thrombosis

    ASJC Scopus subject areas

    • Hematology

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  • Cite this

    Souto, J. C., Remacha, A., Buil, A., Almasyl, L., Blangero, J., & Fontcuberta, J. (2003). Genetic determinants of iron metabolism plasma phenotypes and their relationship with risk of thrombosis. Haematologica, 88(12), 1436-1438.