Genetic determinants of iron metabolism plasma phenotypes and their relationship with risk of thrombosis

Juan Carlos Souto; Angel Remacha; Alfonso Buil; Laura Almasyl; John Blangero; Jordi Fontcuberta

Genetic determinants of iron metabolism plasma phenotypes and their relationship with risk of thrombosis

Juan Carlos Souto, Angel Remacha, Alfonso Buil, Laura Almasyl, John Blangero, Jordi Fontcuberta

Research output: Contribution to journal › Article › peer-review

Abstract

This study evaluates the relative contributions of genetic and environmental factors to 6 iron-related phenotypes and the relationship between these phenotypes and the risk of thrombosis. All of these phenotypes were influenced significantly by genetics, with heritability ranging between 180% for transferrin saturation to 55% for soluble transferrin receptor (sTfR). Only sTfR exhibited a significant genetic correlation with thrombosis.

Original language	English (US)
Pages (from-to)	1436-1438
Number of pages	3
Journal	Haematologica
Volume	88
Issue number	12
State	Published - Dec 2003

Keywords

Family studies
Genetics
Heritability
Iron metabolism
Thrombosis

ASJC Scopus subject areas

Hematology

Cite this

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abstract = "This study evaluates the relative contributions of genetic and environmental factors to 6 iron-related phenotypes and the relationship between these phenotypes and the risk of thrombosis. All of these phenotypes were influenced significantly by genetics, with heritability ranging between 180% for transferrin saturation to 55% for soluble transferrin receptor (sTfR). Only sTfR exhibited a significant genetic correlation with thrombosis.",

keywords = "Family studies, Genetics, Heritability, Iron metabolism, Thrombosis",

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AU - Souto, Juan Carlos

AU - Remacha, Angel

AU - Buil, Alfonso

AU - Almasyl, Laura

AU - Blangero, John

AU - Fontcuberta, Jordi

PY - 2003/12

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AB - This study evaluates the relative contributions of genetic and environmental factors to 6 iron-related phenotypes and the relationship between these phenotypes and the risk of thrombosis. All of these phenotypes were influenced significantly by genetics, with heritability ranging between 180% for transferrin saturation to 55% for soluble transferrin receptor (sTfR). Only sTfR exhibited a significant genetic correlation with thrombosis.

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KW - Genetics

KW - Heritability

KW - Iron metabolism

KW - Thrombosis

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Genetic determinants of iron metabolism plasma phenotypes and their relationship with risk of thrombosis

Abstract

Keywords

ASJC Scopus subject areas

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