Genetic determinants of cutaneous malignant melanoma in Sinclair swine

J. Blangero, R. G. Tissot, C. W. Beattie, M. S. Amoss

    Research output: Contribution to journalArticle

    26 Scopus citations

    Abstract

    The role of genetic factors involved in the determination of risk of cutaneous malignant melanoma (CMM) in humans remains unclear owing to genetic heterogeneity and reliance on simplistic models of inheritance. Here, we report a statistical genetic analysis of cutaneous malignant melanoma in Sinclair swine (SSCM), a unique animal model for human CMM. Using complex segregation analysis a two-locus model involving an unknown major locus and a second locus that lies within or close to the swine leucocytic antigen (SLA) complex jointly determine risk of SSCM in pedigreed animals. These loci also influence severity of affection, accounting for approximately 20% of the phenotypic variation in quantitative tumour burden.

    Original languageEnglish (US)
    Pages (from-to)667-671
    Number of pages5
    JournalBritish Journal of Cancer
    Volume73
    Issue number5
    DOIs
    StatePublished - Jan 1 1996

      Fingerprint

    Keywords

    • Animal model
    • Linkage analysis
    • Melanoma
    • Segregation analysis

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

    Cite this

    Blangero, J., Tissot, R. G., Beattie, C. W., & Amoss, M. S. (1996). Genetic determinants of cutaneous malignant melanoma in Sinclair swine. British Journal of Cancer, 73(5), 667-671. https://doi.org/10.1038/bjc.1996.116