Genetic determinants of cutaneous malignant melanoma in Sinclair swine

J. Blangero, R. G. Tissot, C. W. Beattie, M. S. Amoss

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The role of genetic factors involved in the determination of risk of cutaneous malignant melanoma (CMM) in humans remains unclear owing to genetic heterogeneity and reliance on simplistic models of inheritance. Here, we report a statistical genetic analysis of cutaneous malignant melanoma in Sinclair swine (SSCM), a unique animal model for human CMM. Using complex segregation analysis a two-locus model involving an unknown major locus and a second locus that lies within or close to the swine leucocytic antigen (SLA) complex jointly determine risk of SSCM in pedigreed animals. These loci also influence severity of affection, accounting for approximately 20% of the phenotypic variation in quantitative tumour burden.

Original languageEnglish (US)
Pages (from-to)667-671
Number of pages5
JournalBritish Journal of Cancer
Volume73
Issue number5
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Animal model
  • Linkage analysis
  • Melanoma
  • Segregation analysis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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