Genetic Determinant of Lithium Ion Metabolism: II. An in Vivo Study of Lithium Ion Distribution Across Erythrocyte Membranes

Arthur P. Schless, Alan Frazer, Joe Mendels, Ghanshyam N. Pandey, Vassilios J. Theodorides

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

A study was conducted to determine if membrane factors, known to influence the distribution of sodium ion (Na) and potassium ion (K), also influence lithium ion distribution. Two groups of sheep with genetically determined differences in their cation concentrations were administered lithium chloride for ten days. The low red blood cell (RBC) potassium ion sheep (LK) had a greater RBC lithium ion concentration than the high RBC potassium ion sheep (HK). In vitro incubation of erythrocytes with lithium chloride also produced substantially different RBC lithium ion: plasma lithium ion ratios similar to those seen in the in vivo study. Distribution of lithium ion was generally similar to that of Na ion. It seems that lithium ion distribution may be controlled by the same genetic factors that regulate Na ion distribution.

Original languageEnglish (US)
Pages (from-to)337-340
Number of pages4
JournalArchives of General Psychiatry
Volume32
Issue number3
DOIs
StatePublished - Mar 1975
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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