TY - JOUR
T1 - Genetic Determinant of Lithium Ion Distribution
T2 - I. An in Vitro Monozygotic-Dizygotic Twin Study
AU - Dorus, Elizabeth
AU - Pandey, Ghanshayam N.
AU - Frazer, Alan
AU - Mendels, Joe
PY - 1974/10
Y1 - 1974/10
N2 - Research in pharmacogenetics has provided evidence that individual variation in rate of metabolism of various drugs is genetically controlled. To evaluate the possibility of a genetic determinant of lithium ion distribution, a monozygotic (MZ)-dizygotic (DZ) twin study method was used. Red blood cell (RBC) lithium ion concentrations were assessed for ten MZ and seven DZ twin pairs following a 24-hour incubation in vitro. The distributions of intrapair difference scores of MZ twin pairs and DZ twin pairs were relatively nonoverlapping, with MZ intrapair difference scores being smaller on the average. A heritability index of 0.85, calculated as a function of intrapair difference scores, indicated that a substantial genetic factor is operative in RBC uptake of lithium ion.
AB - Research in pharmacogenetics has provided evidence that individual variation in rate of metabolism of various drugs is genetically controlled. To evaluate the possibility of a genetic determinant of lithium ion distribution, a monozygotic (MZ)-dizygotic (DZ) twin study method was used. Red blood cell (RBC) lithium ion concentrations were assessed for ten MZ and seven DZ twin pairs following a 24-hour incubation in vitro. The distributions of intrapair difference scores of MZ twin pairs and DZ twin pairs were relatively nonoverlapping, with MZ intrapair difference scores being smaller on the average. A heritability index of 0.85, calculated as a function of intrapair difference scores, indicated that a substantial genetic factor is operative in RBC uptake of lithium ion.
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U2 - 10.1001/archpsyc.1974.01760160019005
DO - 10.1001/archpsyc.1974.01760160019005
M3 - Article
C2 - 4473122
AN - SCOPUS:0016251336
SN - 0003-990X
VL - 31
SP - 463
EP - 465
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 4
ER -