Genetic Crosses and Linkage Mapping in Schistosome Parasites

Timothy JC Anderson; Philip T. LoVerde; Winka Le Clec'h; Frédéric D. Chevalier

doi:10.1016/j.pt.2018.08.001

Genetic Crosses and Linkage Mapping in Schistosome Parasites

Timothy JC Anderson, Philip T. LoVerde, Winka Le Clec'h, Frédéric D. Chevalier

Department of Biochemistry & Structural Biology

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Linkage mapping – utilizing experimental genetic crosses to examine cosegregation of phenotypic traits with genetic markers – is now 100 years old. Schistosome parasites are exquisitely well suited to linkage mapping approaches because genetic crosses can be conducted in the laboratory, thousands of progeny are produced, and elegant experimental work over the last 75 years has revealed heritable genetic variation in multiple biomedically important traits such as drug resistance, host specificity, and virulence. Application of this approach is timely because the improved genome assembly for Schistosoma mansoni and developing molecular toolkit for schistosomes increase our ability to link phenotype with genotype. We describe current progress and potential future directions of linkage mapping in schistosomes.

Original language	English (US)
Pages (from-to)	982-996
Number of pages	15
Journal	Trends in Parasitology
Volume	34
Issue number	11
DOIs	https://doi.org/10.1016/j.pt.2018.08.001
State	Published - Nov 2018

Keywords

Schistosoma
fine mapping
functional analysis
heritability
linkage
phenotype

ASJC Scopus subject areas

Infectious Diseases
Parasitology

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10.1016/j.pt.2018.08.001

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title = "Genetic Crosses and Linkage Mapping in Schistosome Parasites",

abstract = "Linkage mapping – utilizing experimental genetic crosses to examine cosegregation of phenotypic traits with genetic markers – is now 100 years old. Schistosome parasites are exquisitely well suited to linkage mapping approaches because genetic crosses can be conducted in the laboratory, thousands of progeny are produced, and elegant experimental work over the last 75 years has revealed heritable genetic variation in multiple biomedically important traits such as drug resistance, host specificity, and virulence. Application of this approach is timely because the improved genome assembly for Schistosoma mansoni and developing molecular toolkit for schistosomes increase our ability to link phenotype with genotype. We describe current progress and potential future directions of linkage mapping in schistosomes.",

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AU - Anderson, Timothy JC

AU - LoVerde, Philip T.

AU - Le Clec'h, Winka

AU - Chevalier, Frédéric D.

PY - 2018/11

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N2 - Linkage mapping – utilizing experimental genetic crosses to examine cosegregation of phenotypic traits with genetic markers – is now 100 years old. Schistosome parasites are exquisitely well suited to linkage mapping approaches because genetic crosses can be conducted in the laboratory, thousands of progeny are produced, and elegant experimental work over the last 75 years has revealed heritable genetic variation in multiple biomedically important traits such as drug resistance, host specificity, and virulence. Application of this approach is timely because the improved genome assembly for Schistosoma mansoni and developing molecular toolkit for schistosomes increase our ability to link phenotype with genotype. We describe current progress and potential future directions of linkage mapping in schistosomes.

AB - Linkage mapping – utilizing experimental genetic crosses to examine cosegregation of phenotypic traits with genetic markers – is now 100 years old. Schistosome parasites are exquisitely well suited to linkage mapping approaches because genetic crosses can be conducted in the laboratory, thousands of progeny are produced, and elegant experimental work over the last 75 years has revealed heritable genetic variation in multiple biomedically important traits such as drug resistance, host specificity, and virulence. Application of this approach is timely because the improved genome assembly for Schistosoma mansoni and developing molecular toolkit for schistosomes increase our ability to link phenotype with genotype. We describe current progress and potential future directions of linkage mapping in schistosomes.

KW - Schistosoma

KW - fine mapping

KW - functional analysis

KW - heritability

KW - linkage

KW - phenotype

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Genetic Crosses and Linkage Mapping in Schistosome Parasites

Abstract

Keywords

ASJC Scopus subject areas

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