Genetic Crosses and Linkage Mapping in Schistosome Parasites

Timothy J.C. Anderson, Philip T. LoVerde, Winka Le Clec'h, Frédéric D. Chevalier

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Linkage mapping – utilizing experimental genetic crosses to examine cosegregation of phenotypic traits with genetic markers – is now 100 years old. Schistosome parasites are exquisitely well suited to linkage mapping approaches because genetic crosses can be conducted in the laboratory, thousands of progeny are produced, and elegant experimental work over the last 75 years has revealed heritable genetic variation in multiple biomedically important traits such as drug resistance, host specificity, and virulence. Application of this approach is timely because the improved genome assembly for Schistosoma mansoni and developing molecular toolkit for schistosomes increase our ability to link phenotype with genotype. We describe current progress and potential future directions of linkage mapping in schistosomes.

Original languageEnglish (US)
Pages (from-to)982-996
Number of pages15
JournalTrends in Parasitology
Volume34
Issue number11
DOIs
StatePublished - Nov 2018

Keywords

  • Schistosoma
  • fine mapping
  • functional analysis
  • heritability
  • linkage
  • phenotype

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Genetic Crosses and Linkage Mapping in Schistosome Parasites'. Together they form a unique fingerprint.

Cite this