Genetic component to susceptibility to Trichuris trichiura: Evidence from two Asian populations

Sarah Williams-Blangero, Stephen T. McGarvey, Janardan Subedi, Peter M. Wiest, Ram Prasad Upadhayay, Dev R. Rai, Bharat Jha, G. Richard Olds, Wu Guanling, John Blangero

    Research output: Contribution to journalArticlepeer-review

    40 Scopus citations

    Abstract

    Trichuris trichiura is an helminthic infection with potentially severe health consequences. The hypothesis that host genetic factors can account for the distribution of Trichuris was tested using familial data on egg counts available for two populations, the Jirels of Nepal and the population of Jishan Island in Jiangxi Province of the People's Republic of China. Whipworm is highly prevalent in the Jishan Island population (86%), but occurs at a low rate in the Jirel population (14%). A quantitative genetic analysis was performed on each data set, using a variance component approach. Approximately 28% of the variation in Trichuris trichiura loads was attributable to genetic factors in both populations. Common household effects accounted for only 4% of the variation in the Jirels and none of the variation in the Jishan Island population. These concordant results from two separate populations provide strong evidence of the important role of genetics in determining differential susceptibility to whipworm infection.

    Original languageEnglish (US)
    Pages (from-to)254-264
    Number of pages11
    JournalGenetic epidemiology
    Volume22
    Issue number3
    DOIs
    StatePublished - 2002

    Keywords

    • Parasitology
    • Variance components
    • Whipworm

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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