Genetic Characterization of Three Distinct Mechanisms Supporting RNA-Driven DNA Repair and Modification Reveals Major Role of DNA Polymerase ζ

Chance Meers; Havva Keskin; Gabor Banyai; Olga Mazina; Taehwan Yang; Alli L. Gombolay; Kuntal Mukherjee; Efiyenia I. Kaparos; Gary Newnam; Alexander Mazin; Francesca Storici

doi:10.1016/j.molcel.2020.08.011

Genetic Characterization of Three Distinct Mechanisms Supporting RNA-Driven DNA Repair and Modification Reveals Major Role of DNA Polymerase ζ

Chance Meers
, Havva Keskin
, Gabor Banyai
, Olga Mazina
, Taehwan Yang
, Alli L. Gombolay
, Kuntal Mukherjee
, Efiyenia I. Kaparos
, Gary Newnam
, Alexander Mazin
, Francesca Storici

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Still much is unknown about the roles of RNA in DNA repair and modification. Meers et al. characterize three genetic mechanisms by which RNA can directly or indirectly transfer genetic information to DNA in yeast cells and uncover that direct RNA-templated DNA recombination is aided by translesion DNA polymerase ζ.

Original language	English (US)
Pages (from-to)	1037-1050.e5
Journal	Molecular Cell
Volume	79
Issue number	6
DOIs	https://doi.org/10.1016/j.molcel.2020.08.011
State	Published - Sep 17 2020
Externally published	Yes

Keywords

DNA polymerase ζ
DNA repair
REV3
RNA recombination
RNA-mediated
RNA-templated
cDNA-mediated
homologous recombination
reverse transcriptase
translesion polymerase

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2020.08.011

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Meers, C., Keskin, H., Banyai, G., Mazina, O., Yang, T., Gombolay, A. L., Mukherjee, K., Kaparos, E. I., Newnam, G., Mazin, A., & Storici, F. (2020). Genetic Characterization of Three Distinct Mechanisms Supporting RNA-Driven DNA Repair and Modification Reveals Major Role of DNA Polymerase ζ. Molecular Cell, 79(6), 1037-1050.e5. https://doi.org/10.1016/j.molcel.2020.08.011

Meers, C, Keskin, H, Banyai, G, Mazina, O, Yang, T, Gombolay, AL, Mukherjee, K, Kaparos, EI, Newnam, G, Mazin, A & Storici, F 2020, 'Genetic Characterization of Three Distinct Mechanisms Supporting RNA-Driven DNA Repair and Modification Reveals Major Role of DNA Polymerase ζ', Molecular Cell, vol. 79, no. 6, pp. 1037-1050.e5. https://doi.org/10.1016/j.molcel.2020.08.011

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abstract = "Still much is unknown about the roles of RNA in DNA repair and modification. Meers et al. characterize three genetic mechanisms by which RNA can directly or indirectly transfer genetic information to DNA in yeast cells and uncover that direct RNA-templated DNA recombination is aided by translesion DNA polymerase ζ.",

keywords = "DNA polymerase ζ, DNA repair, REV3, RNA recombination, RNA-mediated, RNA-templated, cDNA-mediated, homologous recombination, reverse transcriptase, translesion polymerase",

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doi = "10.1016/j.molcel.2020.08.011",

language = "English (US)",

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T1 - Genetic Characterization of Three Distinct Mechanisms Supporting RNA-Driven DNA Repair and Modification Reveals Major Role of DNA Polymerase ζ

AU - Meers, Chance

AU - Keskin, Havva

AU - Banyai, Gabor

AU - Mazina, Olga

AU - Yang, Taehwan

AU - Gombolay, Alli L.

AU - Mukherjee, Kuntal

AU - Kaparos, Efiyenia I.

AU - Newnam, Gary

AU - Mazin, Alexander

AU - Storici, Francesca

PY - 2020/9/17

Y1 - 2020/9/17

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AB - Still much is unknown about the roles of RNA in DNA repair and modification. Meers et al. characterize three genetic mechanisms by which RNA can directly or indirectly transfer genetic information to DNA in yeast cells and uncover that direct RNA-templated DNA recombination is aided by translesion DNA polymerase ζ.

KW - DNA polymerase ζ

KW - DNA repair

KW - REV3

KW - RNA recombination

KW - RNA-mediated

KW - RNA-templated

KW - cDNA-mediated

KW - homologous recombination

KW - reverse transcriptase

KW - translesion polymerase

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UR - https://www.scopus.com/pages/publications/85090700979#tab=citedBy

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DO - 10.1016/j.molcel.2020.08.011

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C2 - 32882183

AN - SCOPUS:85090700979

SN - 1097-2765

VL - 79

SP - 1037-1050.e5

JO - Molecular Cell

JF - Molecular Cell

IS - 6

ER -

Genetic Characterization of Three Distinct Mechanisms Supporting RNA-Driven DNA Repair and Modification Reveals Major Role of DNA Polymerase ζ

Abstract

Keywords

ASJC Scopus subject areas

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