TY - JOUR
T1 - Genetic characterization and phylogeny of Sabia virus, an emergent pathogen in Brazil
AU - Gonzalez, Jean Paul J.
AU - Bowen, Michael D.
AU - Nichol, Stuart T.
AU - Rico-Hesse, Rebeca
N1 - Funding Information:
This work was supported in part by Grants A1-10984 and A1-01124 from the National Institutes of Health, and DES-AB8004 from the Institut Franc¸ais de Recherche Scientifique pour le Développement en Coopéra-tion. We thank our Brazilian colleagues for providing the Sabiá prototype virus.
PY - 1996/7/15
Y1 - 1996/7/15
N2 - Sabia virus, one of five arenaviruses from South America known to cause hemorrhagic fever in humans, emerged in 1990 when it was isolated from a fatal case in Sao Paulo, Brazil. Subsequently, it has caused two laboratory- acquired infections. Its natural distribution and host are still unknown. Using viral RNA and multiple polymerase chain reaction products as templates, the nucleotide sequence of the small (S) RNA segment of Sabia virus, which codes for the nucleocapsid (N) and glycoprotein precursor, was determined. This virus shares an ambisense genome in common with other arenaviruses, although it has a unique predicted three stem loop structure in the S RNA intergenic region. Phylogenetic analysis of a portion of the N gene sequence confirmed that Sabia virus is distinct from all other members of the Arenaviridae and shares a progenitor with Junin, Machupo, Tacaribe, and Guanarito viruses.
AB - Sabia virus, one of five arenaviruses from South America known to cause hemorrhagic fever in humans, emerged in 1990 when it was isolated from a fatal case in Sao Paulo, Brazil. Subsequently, it has caused two laboratory- acquired infections. Its natural distribution and host are still unknown. Using viral RNA and multiple polymerase chain reaction products as templates, the nucleotide sequence of the small (S) RNA segment of Sabia virus, which codes for the nucleocapsid (N) and glycoprotein precursor, was determined. This virus shares an ambisense genome in common with other arenaviruses, although it has a unique predicted three stem loop structure in the S RNA intergenic region. Phylogenetic analysis of a portion of the N gene sequence confirmed that Sabia virus is distinct from all other members of the Arenaviridae and shares a progenitor with Junin, Machupo, Tacaribe, and Guanarito viruses.
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U2 - 10.1006/viro.1996.0381
DO - 10.1006/viro.1996.0381
M3 - Article
C2 - 8661442
AN - SCOPUS:0030586018
VL - 221
SP - 318
EP - 324
JO - Virology
JF - Virology
SN - 0042-6822
IS - 2
ER -