Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia

E. Fitzpatrick, M. P. Johnson, T. D. Dyer, S. Forrest, K. Elliott, J. Blangero, S. P. Brennecke, E. K. Moses

    Research output: Contribution to journalArticle

    27 Scopus citations

    Abstract

    Pre-eclampsia is a common serious disorder of human pregnancy, which is associated with significant maternal and perinatal morbidity and mortality. The suspected aetiology of pre-eclampsia is complex, with susceptibility being attributable to multiple environmental factors and a large genetic component. Recently, we reported significant linkage to chromosome 2q22 in 34 Australian/New Zealand (Aust/NZ) pre-eclampsia/ eclampsia families, and activin A receptor type IIA (ACVR2A) was identified as a strong positional candidate gene at this locus. In an attempt to identify the putative risk variants, we have now comprehensively re-sequenced the entire coding region of the ACVR2A gene and the conserved non-coding sequences in a subset of 16 individuals from these families. We identified 45 single nucleotide polymorphisms (SNPs), with 9 being novel. These SNPs were genotyped in our total family sample of 480 individuals from 74 Aust/NZ pre-eclampsia families (including the original 34 genome-scanned families). Our best associations between ACVR2A polymorphisms and pre-eclampsia were for rs10497025 (P = 0.025), rs13430086 (P = 0.010) and three novel SNPs: LF004, LF013 and LF020 (all with P = 0.018). After correction for multiple hypothesis testing, none of these associations reached significance (P > 0.05). Based on these data, it remains unclear what role, if any, ACVR2A polymorphisms play in pre-eclampsia risk, at least in these Australian families. However, it would be premature to rule out this gene as significant associations between ACVR2A SNPs and pre-eclampsia have recently been reported in a large Norwegian (HUNT) population sample.

    Original languageEnglish (US)
    Pages (from-to)195-204
    Number of pages10
    JournalMolecular Human Reproduction
    Volume15
    Issue number3
    DOIs
    StatePublished - Mar 11 2009

    Keywords

    • ACVR2A
    • Activin
    • Genetic association
    • Pre-eclampsia
    • SNP

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Embryology
    • Molecular Biology
    • Genetics
    • Obstetrics and Gynecology
    • Developmental Biology
    • Cell Biology

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  • Cite this

    Fitzpatrick, E., Johnson, M. P., Dyer, T. D., Forrest, S., Elliott, K., Blangero, J., Brennecke, S. P., & Moses, E. K. (2009). Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia. Molecular Human Reproduction, 15(3), 195-204. https://doi.org/10.1093/molehr/gap001