Genetic association of preeclampsia to the inflammatory response gene SEPS1

Eric K. Moses, Matthew P. Johnson, Linda Tømmerdal, Siri Forsmo, Joanne E. Curran, Lawrence J. Abraham, Jac C. Charlesworth, Shaun P. Brennecke, John Blangero, Rigmor Austgulen

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Objective: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia. Study Design: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n = 1139) and control (n = 2269) women. Statistical significance was determined by χ2 and multivariate regression analyses. Results: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P = .0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P = .023; odds ratio, 1.22; 95% CI, 1.02 to 1.46). Conclusion: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.

Original languageEnglish (US)
Pages (from-to)336.e1-336.e5
JournalAmerican Journal of Obstetrics and Gynecology
Volume198
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Keywords

  • SEPS1
  • genetic association
  • inflammation
  • polymorphism
  • preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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