Abstract
Objective: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia. Study Design: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n = 1139) and control (n = 2269) women. Statistical significance was determined by χ2 and multivariate regression analyses. Results: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P = .0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P = .023; odds ratio, 1.22; 95% CI, 1.02 to 1.46). Conclusion: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.
Original language | English (US) |
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Pages (from-to) | 336.e1-336.e5 |
Journal | American Journal of Obstetrics and Gynecology |
Volume | 198 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2008 |
Keywords
- SEPS1
- genetic association
- inflammation
- polymorphism
- preeclampsia
ASJC Scopus subject areas
- Obstetrics and Gynecology