Genetic association of preeclampsia to the inflammatory response gene SEPS1

Eric K. Moses; Matthew P. Johnson; Linda Tømmerdal; Siri Forsmo; Joanne E. Curran; Lawrence J. Abraham; Jac C. Charlesworth; Shaun P. Brennecke; John Blangero; Rigmor Austgulen

doi:10.1016/j.ajog.2007.09.024

Genetic association of preeclampsia to the inflammatory response gene SEPS1

Eric K. Moses, Matthew P. Johnson, Linda Tømmerdal, Siri Forsmo, Joanne E. Curran, Lawrence J. Abraham, Jac C. Charlesworth, Shaun P. Brennecke, John Blangero, Rigmor Austgulen

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Objective: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia. Study Design: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n = 1139) and control (n = 2269) women. Statistical significance was determined by χ² and multivariate regression analyses. Results: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P = .0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P = .023; odds ratio, 1.22; 95% CI, 1.02 to 1.46). Conclusion: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.

Original language	English (US)
Pages (from-to)	336.e1-336.e5
Journal	American Journal of Obstetrics and Gynecology
Volume	198
Issue number	3
DOIs	https://doi.org/10.1016/j.ajog.2007.09.024
State	Published - Mar 2008

Keywords

SEPS1
genetic association
inflammation
polymorphism
preeclampsia

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2007.09.024

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Genetic association of preeclampsia to the inflammatory response gene SEPS1. / Moses, Eric K.; Johnson, Matthew P.; Tømmerdal, Linda; Forsmo, Siri; Curran, Joanne E.; Abraham, Lawrence J.; Charlesworth, Jac C.; Brennecke, Shaun P.; Blangero, John; Austgulen, Rigmor.

In: American Journal of Obstetrics and Gynecology, Vol. 198, No. 3, 03.2008, p. 336.e1-336.e5.

Research output: Contribution to journal › Article › peer-review

Moses, Eric K. ; Johnson, Matthew P. ; Tømmerdal, Linda ; Forsmo, Siri ; Curran, Joanne E. ; Abraham, Lawrence J. ; Charlesworth, Jac C. ; Brennecke, Shaun P. ; Blangero, John ; Austgulen, Rigmor. / Genetic association of preeclampsia to the inflammatory response gene SEPS1. In: American Journal of Obstetrics and Gynecology. 2008 ; Vol. 198, No. 3. pp. 336.e1-336.e5.

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title = "Genetic association of preeclampsia to the inflammatory response gene SEPS1",

abstract = "Objective: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia. Study Design: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n = 1139) and control (n = 2269) women. Statistical significance was determined by χ2 and multivariate regression analyses. Results: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P = .0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P = .023; odds ratio, 1.22; 95% CI, 1.02 to 1.46). Conclusion: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.",

keywords = "SEPS1, genetic association, inflammation, polymorphism, preeclampsia",

author = "Moses, {Eric K.} and Johnson, {Matthew P.} and Linda T{\o}mmerdal and Siri Forsmo and Curran, {Joanne E.} and Abraham, {Lawrence J.} and Charlesworth, {Jac C.} and Brennecke, {Shaun P.} and John Blangero and Rigmor Austgulen",

note = "Funding Information: This work was supported in part by grants from the Central Norway Regional Health Authority and the Medical Faculty and Office of International Relations at the Norwegian University of Science and Technology (to L..), the Andrew Cowles Postdoctoral Fellowship (to M.P.J.), National Institutes of Health Grant MH59490 (to J.B.), and the Elizabeth Huth Coates Charitable Foundation (to E.K.M.). Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2008",

month = mar,

doi = "10.1016/j.ajog.2007.09.024",

language = "English (US)",

volume = "198",

pages = "336.e1--336.e5",

journal = "American Journal of Obstetrics and Gynecology",

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T1 - Genetic association of preeclampsia to the inflammatory response gene SEPS1

AU - Moses, Eric K.

AU - Johnson, Matthew P.

AU - Tømmerdal, Linda

AU - Forsmo, Siri

AU - Curran, Joanne E.

AU - Abraham, Lawrence J.

AU - Charlesworth, Jac C.

AU - Brennecke, Shaun P.

AU - Blangero, John

AU - Austgulen, Rigmor

N1 - Funding Information: This work was supported in part by grants from the Central Norway Regional Health Authority and the Medical Faculty and Office of International Relations at the Norwegian University of Science and Technology (to L..), the Andrew Cowles Postdoctoral Fellowship (to M.P.J.), National Institutes of Health Grant MH59490 (to J.B.), and the Elizabeth Huth Coates Charitable Foundation (to E.K.M.). Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2008/3

Y1 - 2008/3

N2 - Objective: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia. Study Design: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n = 1139) and control (n = 2269) women. Statistical significance was determined by χ2 and multivariate regression analyses. Results: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P = .0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P = .023; odds ratio, 1.22; 95% CI, 1.02 to 1.46). Conclusion: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.

AB - Objective: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia. Study Design: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n = 1139) and control (n = 2269) women. Statistical significance was determined by χ2 and multivariate regression analyses. Results: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P = .0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P = .023; odds ratio, 1.22; 95% CI, 1.02 to 1.46). Conclusion: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.

KW - SEPS1

KW - genetic association

KW - inflammation

KW - polymorphism

KW - preeclampsia

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SN - 0002-9378

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Genetic association of preeclampsia to the inflammatory response gene SEPS1

Abstract

Keywords

ASJC Scopus subject areas

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