Genetic association of mating types and virulence in Cryptococcus neoformans

K. J. Kwon-Chung, J. C. Edman, B. L. Wickes

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323 Scopus citations


A pair of congenic Cryptococcus neoformans var. neoformans strains, B-4476 (a mating type) and B-4500 (α mating type), that presumably differ only in mating type was constructed. This pair and their progeny, five α type and five a type, were tested for virulence in mice. In the parent strains as well as the progeny, α type was clearly more virulent than a type. In addition, death tended to occur earlier among the α-strain-infected mice that died than among the mice that died by infection caused by a strains. These data strongly suggest the genetic association of virulence with mating type in this human fungal pathogen.

Original languageEnglish (US)
Pages (from-to)602-605
Number of pages4
JournalInfection and Immunity
Issue number2
StatePublished - Dec 1 1991


ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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