A pair of congenic Cryptococcus neoformans var. neoformans strains, B-4476 (a mating type) and B-4500 (α mating type), that presumably differ only in mating type was constructed. This pair and their progeny, five α type and five a type, were tested for virulence in mice. In the parent strains as well as the progeny, α type was clearly more virulent than a type. In addition, death tended to occur earlier among the α-strain-infected mice that died than among the mice that died by infection caused by a strains. These data strongly suggest the genetic association of virulence with mating type in this human fungal pathogen.
|Original language||English (US)|
|Number of pages||4|
|Journal||Infection and Immunity|
|State||Published - Dec 1 1991|
ASJC Scopus subject areas
- Infectious Diseases