Genetic approaches in preeclampsia

Hannah E.J. Yong, Padma Murthi, Shaun P. Brennecke, Eric K. Moses

    Research output: Chapter in Book/Report/Conference proceedingChapter

    5 Scopus citations

    Abstract

    Preeclampsia (PE) is a serious hypertensive disorder that affects up to 8% of all pregnancies annually. An established risk factor for PE is family history, clearly demonstrating an underlying genetic component to the disorder. To date, numerous genetic studies, using both the candidate gene and genome-wide approach, have been undertaken to tease out the genetic basis of PE and understand its origins. Such studies have identified some promising candidate genes such as STOX1 and ACVR2A. Nevertheless, researchers face ongoing challenges of replicating these genetic associations in different populations and performing the functional validation of identified genetic variants to determine their causality in the disorder. This chapter will review the genetic approaches used in the study of PE, discuss their limitations and possible confounders, and describe current strategies.

    Original languageEnglish (US)
    Title of host publicationMethods in Molecular Biology
    PublisherHumana Press
    Pages53-72
    Number of pages20
    DOIs
    StatePublished - Jan 1 2018

    Publication series

    NameMethods in Molecular Biology
    Volume1710
    ISSN (Print)1064-3745

    Keywords

    • ACVR2A
    • Candidate gene
    • Genetic approaches
    • Genome-wide association
    • Linkage analysis
    • Preeclampsia
    • STOX1
    • Transcriptome profiling

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics

    Fingerprint Dive into the research topics of 'Genetic approaches in preeclampsia'. Together they form a unique fingerprint.

  • Cite this

    Yong, H. E. J., Murthi, P., Brennecke, S. P., & Moses, E. K. (2018). Genetic approaches in preeclampsia. In Methods in Molecular Biology (pp. 53-72). (Methods in Molecular Biology; Vol. 1710). Humana Press. https://doi.org/10.1007/978-1-4939-7498-6_5