Genetic analysis of quantitative traits in highly ascertained samples: Total serum IgE in families with asthma

J. Bethony, J. T. Williams, L. Almasy, R. Corrêa-Oliveira, J. C. Blangero, S. Williams-Blangero

    Research output: Contribution to journalArticle

    4 Scopus citations

    Abstract

    The objective of this study was to compare the effect of an approximate ascertainment correction using proband phenotypes with heuristic corrections based on sample trait means and on published "standard" population values. Data were from the Collaborative Study on the Genetics of Asthma, which comprises 225 families ascertained through sib pairs affected with asthma. In variance component linkage analysis of IgE no lod scores greater than 3.0 were observed, either with or without several attempted corrections for ascertainment. The ascertained nature of the sample may have compromised the power to detect linkage to a quantitative trait (IgE) associated with the focal phenotype (asthma).

    Original languageEnglish (US)
    Pages (from-to)S174-S179
    JournalGenetic epidemiology
    Volume21
    Issue numberSUPPL. 1
    StatePublished - Oct 23 2001

    Keywords

    • Ascertainment asthma
    • Immunoglobulin E (IgE)
    • Statistical genetics

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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    Bethony, J., Williams, J. T., Almasy, L., Corrêa-Oliveira, R., Blangero, J. C., & Williams-Blangero, S. (2001). Genetic analysis of quantitative traits in highly ascertained samples: Total serum IgE in families with asthma. Genetic epidemiology, 21(SUPPL. 1), S174-S179.