Abstract
The objective of this study was to compare the effect of an approximate ascertainment correction using proband phenotypes with heuristic corrections based on sample trait means and on published "standard" population values. Data were from the Collaborative Study on the Genetics of Asthma, which comprises 225 families ascertained through sib pairs affected with asthma. In variance component linkage analysis of IgE no lod scores greater than 3.0 were observed, either with or without several attempted corrections for ascertainment. The ascertained nature of the sample may have compromised the power to detect linkage to a quantitative trait (IgE) associated with the focal phenotype (asthma).
| Original language | English (US) |
|---|---|
| Journal | Genetic Epidemiology |
| Volume | 21 |
| Issue number | SUPPL. 1 |
| State | Published - 2001 |
| Externally published | Yes |
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Keywords
- Ascertainment asthma
- Immunoglobulin E (IgE)
- Statistical genetics
ASJC Scopus subject areas
- Genetics(clinical)
- Epidemiology
Cite this
Genetic analysis of quantitative traits in highly ascertained samples : Total serum IgE in families with asthma. / Bethony, J.; Williams, J. T.; Almasy, L.; Corrêa-Oliveira, R.; Blangero, J. C.; Williams-Blangero, S.
In: Genetic Epidemiology, Vol. 21, No. SUPPL. 1, 2001.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic analysis of quantitative traits in highly ascertained samples
T2 - Total serum IgE in families with asthma
AU - Bethony, J.
AU - Williams, J. T.
AU - Almasy, L.
AU - Corrêa-Oliveira, R.
AU - Blangero, J. C.
AU - Williams-Blangero, S.
PY - 2001
Y1 - 2001
N2 - The objective of this study was to compare the effect of an approximate ascertainment correction using proband phenotypes with heuristic corrections based on sample trait means and on published "standard" population values. Data were from the Collaborative Study on the Genetics of Asthma, which comprises 225 families ascertained through sib pairs affected with asthma. In variance component linkage analysis of IgE no lod scores greater than 3.0 were observed, either with or without several attempted corrections for ascertainment. The ascertained nature of the sample may have compromised the power to detect linkage to a quantitative trait (IgE) associated with the focal phenotype (asthma).
AB - The objective of this study was to compare the effect of an approximate ascertainment correction using proband phenotypes with heuristic corrections based on sample trait means and on published "standard" population values. Data were from the Collaborative Study on the Genetics of Asthma, which comprises 225 families ascertained through sib pairs affected with asthma. In variance component linkage analysis of IgE no lod scores greater than 3.0 were observed, either with or without several attempted corrections for ascertainment. The ascertained nature of the sample may have compromised the power to detect linkage to a quantitative trait (IgE) associated with the focal phenotype (asthma).
KW - Ascertainment asthma
KW - Immunoglobulin E (IgE)
KW - Statistical genetics
UR - http://www.scopus.com/inward/record.url?scp=0034788097&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034788097&partnerID=8YFLogxK
M3 - Article
VL - 21
JO - Genetic Epidemiology
JF - Genetic Epidemiology
SN - 0741-0395
IS - SUPPL. 1
ER -