TY - JOUR
T1 - Genetic analysis of quantitative traits in highly ascertained samples
T2 - Total serum IgE in families with asthma
AU - Bethony, J.
AU - Williams, J. T.
AU - Almasy, L.
AU - Corrêa-Oliveira, R.
AU - Blangero, J. C.
AU - Williams-Blangero, S.
PY - 2001
Y1 - 2001
N2 - The objective of this study was to compare the effect of an approximate ascertainment correction using proband phenotypes with heuristic corrections based on sample trait means and on published "standard" population values. Data were from the Collaborative Study on the Genetics of Asthma, which comprises 225 families ascertained through sib pairs affected with asthma. In variance component linkage analysis of IgE no lod scores greater than 3.0 were observed, either with or without several attempted corrections for ascertainment. The ascertained nature of the sample may have compromised the power to detect linkage to a quantitative trait (IgE) associated with the focal phenotype (asthma).
AB - The objective of this study was to compare the effect of an approximate ascertainment correction using proband phenotypes with heuristic corrections based on sample trait means and on published "standard" population values. Data were from the Collaborative Study on the Genetics of Asthma, which comprises 225 families ascertained through sib pairs affected with asthma. In variance component linkage analysis of IgE no lod scores greater than 3.0 were observed, either with or without several attempted corrections for ascertainment. The ascertained nature of the sample may have compromised the power to detect linkage to a quantitative trait (IgE) associated with the focal phenotype (asthma).
KW - Ascertainment asthma
KW - Immunoglobulin E (IgE)
KW - Statistical genetics
UR - http://www.scopus.com/inward/record.url?scp=0034788097&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034788097&partnerID=8YFLogxK
U2 - 10.1002/gepi.2001.21.s1.s174
DO - 10.1002/gepi.2001.21.s1.s174
M3 - Article
C2 - 11793664
AN - SCOPUS:0034788097
VL - 21
SP - S174-S179
JO - Genetic Epidemiology
JF - Genetic Epidemiology
SN - 0741-0395
IS - SUPPL. 1
ER -