Genetic analysis of quantitative traits in highly ascertained samples

Total serum IgE in families with asthma

J. Bethony, J. T. Williams, L. Almasy, R. Corrêa-Oliveira, J. C. Blangero, S. Williams-Blangero

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The objective of this study was to compare the effect of an approximate ascertainment correction using proband phenotypes with heuristic corrections based on sample trait means and on published "standard" population values. Data were from the Collaborative Study on the Genetics of Asthma, which comprises 225 families ascertained through sib pairs affected with asthma. In variance component linkage analysis of IgE no lod scores greater than 3.0 were observed, either with or without several attempted corrections for ascertainment. The ascertained nature of the sample may have compromised the power to detect linkage to a quantitative trait (IgE) associated with the focal phenotype (asthma).

Original languageEnglish (US)
JournalGenetic Epidemiology
Volume21
Issue numberSUPPL. 1
StatePublished - 2001
Externally publishedYes

Fingerprint

Immunoglobulin E
Asthma
Serum
Lod Score
Phenotype
Population
Power (Psychology)
Heuristics

Keywords

  • Ascertainment asthma
  • Immunoglobulin E (IgE)
  • Statistical genetics

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Bethony, J., Williams, J. T., Almasy, L., Corrêa-Oliveira, R., Blangero, J. C., & Williams-Blangero, S. (2001). Genetic analysis of quantitative traits in highly ascertained samples: Total serum IgE in families with asthma. Genetic Epidemiology, 21(SUPPL. 1).

Genetic analysis of quantitative traits in highly ascertained samples : Total serum IgE in families with asthma. / Bethony, J.; Williams, J. T.; Almasy, L.; Corrêa-Oliveira, R.; Blangero, J. C.; Williams-Blangero, S.

In: Genetic Epidemiology, Vol. 21, No. SUPPL. 1, 2001.

Research output: Contribution to journalArticle

Bethony, J, Williams, JT, Almasy, L, Corrêa-Oliveira, R, Blangero, JC & Williams-Blangero, S 2001, 'Genetic analysis of quantitative traits in highly ascertained samples: Total serum IgE in families with asthma', Genetic Epidemiology, vol. 21, no. SUPPL. 1.
Bethony J, Williams JT, Almasy L, Corrêa-Oliveira R, Blangero JC, Williams-Blangero S. Genetic analysis of quantitative traits in highly ascertained samples: Total serum IgE in families with asthma. Genetic Epidemiology. 2001;21(SUPPL. 1).
Bethony, J. ; Williams, J. T. ; Almasy, L. ; Corrêa-Oliveira, R. ; Blangero, J. C. ; Williams-Blangero, S. / Genetic analysis of quantitative traits in highly ascertained samples : Total serum IgE in families with asthma. In: Genetic Epidemiology. 2001 ; Vol. 21, No. SUPPL. 1.
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