Genetic analysis of quantitative traits in highly ascertained samples: Total serum IgE in families with asthma

J. Bethony; J. T. Williams; L. Almasy; R. Corrêa-Oliveira; J. C. Blangero; S. Williams-Blangero

doi:10.1002/gepi.2001.21.s1.s174

Genetic analysis of quantitative traits in highly ascertained samples: Total serum IgE in families with asthma

J. Bethony, J. T. Williams, L. Almasy, R. Corrêa-Oliveira, J. C. Blangero, S. Williams-Blangero

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The objective of this study was to compare the effect of an approximate ascertainment correction using proband phenotypes with heuristic corrections based on sample trait means and on published "standard" population values. Data were from the Collaborative Study on the Genetics of Asthma, which comprises 225 families ascertained through sib pairs affected with asthma. In variance component linkage analysis of IgE no lod scores greater than 3.0 were observed, either with or without several attempted corrections for ascertainment. The ascertained nature of the sample may have compromised the power to detect linkage to a quantitative trait (IgE) associated with the focal phenotype (asthma).

Original language	English (US)
Pages (from-to)	S174-S179
Journal	Genetic epidemiology
Volume	21
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1002/gepi.2001.21.s1.s174
State	Published - 2001

Keywords

Ascertainment asthma
Immunoglobulin E (IgE)
Statistical genetics

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

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10.1002/gepi.2001.21.s1.s174

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AU - Bethony, J.

AU - Williams, J. T.

AU - Almasy, L.

AU - Corrêa-Oliveira, R.

AU - Blangero, J. C.

AU - Williams-Blangero, S.

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AB - The objective of this study was to compare the effect of an approximate ascertainment correction using proband phenotypes with heuristic corrections based on sample trait means and on published "standard" population values. Data were from the Collaborative Study on the Genetics of Asthma, which comprises 225 families ascertained through sib pairs affected with asthma. In variance component linkage analysis of IgE no lod scores greater than 3.0 were observed, either with or without several attempted corrections for ascertainment. The ascertained nature of the sample may have compromised the power to detect linkage to a quantitative trait (IgE) associated with the focal phenotype (asthma).

KW - Ascertainment asthma

KW - Immunoglobulin E (IgE)

KW - Statistical genetics

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Genetic analysis of quantitative traits in highly ascertained samples: Total serum IgE in families with asthma

Abstract

Keywords

ASJC Scopus subject areas

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