Genetic analysis of ageing: Role of oxidative damage and environmental stresses

George M. Martin, Steven N. Austad, Thomas E. Johnson

Research output: Contribution to journalReview articlepeer-review

525 Scopus citations

Abstract

Evolutionary theory predicts substantial interspecific and intraspecific differences in the proximal mechanisms of ageing. Our goal here is to seek evidence for common ('public') mechanisms among diverse organisms amenable to genetic analysis. Oxidative damage is a candidate for such a public mechanism of ageing. Long-lived strains are relatively resistant to different environmental stresses. The extent to which these stresses produce oxidative damage remains to be established.

Original languageEnglish (US)
Pages (from-to)25-34
Number of pages10
JournalNature Genetics
Volume13
Issue number1
DOIs
StatePublished - May 1 1996

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Genetic analysis of ageing: Role of oxidative damage and environmental stresses'. Together they form a unique fingerprint.

Cite this