Abstract
Axon outgrowth during development and neurotransmitter release depends on exocytotic mechanisms, although what protein machinery is common to or differentiates these processes remains unclear. Here we show that the neural t-SNARE (target-membrane-associated-soluble N-ethylmaleimide fusion protein attachment protein (SNAP) receptor) SNAP-25 is not required for nerve growth or stimulus-independent neurotransmitter release, but is essential for evoked synaptic transmission at neuromuscular junctions and central synapses. These results demonstrate that the development of neurotransmission requires the recruitment of a specialized SNARE core complex to meet the demands of regulated exocytosis.
Original language | English (US) |
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Pages (from-to) | 19-26 |
Number of pages | 8 |
Journal | Nature Neuroscience |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2002 |
ASJC Scopus subject areas
- Neuroscience(all)