Genes on chromosomes 1 and 13 have significant effects on Ascaris infection

Sarah Williams-Blangero, John L. Vandeberg, Janardan Subedi, Mary Jo Aivaliotis, Dev Raj Rai, Ram Prasad Upadhayay, Bharat Jha, John Blangero

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102 Scopus citations


Nematode parasites show a characteristic aggregated distribution among hosts. This observation has important implications for pathogenesis, immunology, and control of these infections, but the relative roles of environment and genetics in determining these patterns have remained uncertain. This paper presents the results of the first genome scan for susceptibility to infection with roundworm (Ascaris lumbricoides). Data on 375 genetic markers were generated for each of 444 members of a genetically isolated Nepalese population, the Jirels. Ascaris worm burden as assessed by egg counts was measured in these same individuals by using the Kato Katz thick smear method. The extensive genealogical data available for the population allowed assignment of all 444 individuals to a single pedigree that contained 6,209 pairs of relatives that were informative for genetic analysis. A variance components linkage analysis resulted in the unequivocal localization of two genes (one on chromosome 1 and another on chromosome 13) with clear, significant effects on susceptibility to Ascaris infection. This is the first evidence that individual quantitative trait loci influence variation in Ascaris burden in humans.

Original languageEnglish (US)
Pages (from-to)5533-5538
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number8
StatePublished - Apr 16 2002
Externally publishedYes

ASJC Scopus subject areas

  • General


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