Genes for insulin I and II, parathyroid hormone, and calcitonin are on rat chromosome 1

S. Todd, M. C. Yoshida, X. E. Fang, L. McDonald, J. Jacobs, G. Heinrich, G. I. Bell, S. L. Naylor, A. Y. Sakaguchi

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Insulin, parathyroid hormone, and calcitonin are polypeptide hormones that regulate important physiological processes in target tissues. Rat genes encoding each hormone were chromosomally assigned to rat chromosome 1. Both rats and mice have two insulin genes (I and II). However, in contrast to mice in which insulin I and II are asyntenic, rat insulin I and II were both localized to chromosome 1. This study identifies a conserved syntenic group on rat chromosome 1, and implies that mouse insulin I and II genes were chromosomally separated after rats and mice diverged 20-35 million years ago.

Original languageEnglish (US)
Pages (from-to)1175-1180
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume131
Issue number3
DOIs
StatePublished - Sep 30 1985

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Todd, S., Yoshida, M. C., Fang, X. E., McDonald, L., Jacobs, J., Heinrich, G., Bell, G. I., Naylor, S. L., & Sakaguchi, A. Y. (1985). Genes for insulin I and II, parathyroid hormone, and calcitonin are on rat chromosome 1. Biochemical and Biophysical Research Communications, 131(3), 1175-1180. https://doi.org/10.1016/0006-291X(85)90214-1