Genes for insulin I and II, parathyroid hormone, and calcitonin are on rat chromosome 1

S. Todd; M. C. Yoshida; X. E. Fang; L. McDonald; J. Jacobs; G. Heinrich; G. I. Bell; S. L. Naylor; A. Y. Sakaguchi

doi:10.1016/0006-291X(85)90214-1

Genes for insulin I and II, parathyroid hormone, and calcitonin are on rat chromosome 1

S. Todd, M. C. Yoshida, X. E. Fang, L. McDonald, J. Jacobs, G. Heinrich, G. I. Bell, S. L. Naylor, A. Y. Sakaguchi

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

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Abstract

Insulin, parathyroid hormone, and calcitonin are polypeptide hormones that regulate important physiological processes in target tissues. Rat genes encoding each hormone were chromosomally assigned to rat chromosome 1. Both rats and mice have two insulin genes (I and II). However, in contrast to mice in which insulin I and II are asyntenic, rat insulin I and II were both localized to chromosome 1. This study identifies a conserved syntenic group on rat chromosome 1, and implies that mouse insulin I and II genes were chromosomally separated after rats and mice diverged 20-35 million years ago.

Original language	English (US)
Pages (from-to)	1175-1180
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	131
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(85)90214-1
State	Published - Sep 30 1985

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(85)90214-1

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@article{03efbb997bc44f8a8c95f31b577cc453,

title = "Genes for insulin I and II, parathyroid hormone, and calcitonin are on rat chromosome 1",

abstract = "Insulin, parathyroid hormone, and calcitonin are polypeptide hormones that regulate important physiological processes in target tissues. Rat genes encoding each hormone were chromosomally assigned to rat chromosome 1. Both rats and mice have two insulin genes (I and II). However, in contrast to mice in which insulin I and II are asyntenic, rat insulin I and II were both localized to chromosome 1. This study identifies a conserved syntenic group on rat chromosome 1, and implies that mouse insulin I and II genes were chromosomally separated after rats and mice diverged 20-35 million years ago.",

author = "S. Todd and Yoshida, {M. C.} and Fang, {X. E.} and L. McDonald and J. Jacobs and G. Heinrich and Bell, {G. I.} and Naylor, {S. L.} and Sakaguchi, {A. Y.}",

note = "Funding Information: We thank M. Yanagimachi for skilled technical assistance, E. Fisher and B. Russell for typing the manuscript, and B. Bowman for use of equipment and facilities. This study was supported by CA39186 from the National Cancer Institute (A.Y.S.); and Cancer Research from the Ministry of Education Science and Culture, and Society for Promotion of Cancer Research, Japan (M.C.Y.).",

year = "1985",

month = sep,

day = "30",

doi = "10.1016/0006-291X(85)90214-1",

language = "English (US)",

volume = "131",

pages = "1175--1180",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Genes for insulin I and II, parathyroid hormone, and calcitonin are on rat chromosome 1

AU - Todd, S.

AU - Yoshida, M. C.

AU - Fang, X. E.

AU - McDonald, L.

AU - Jacobs, J.

AU - Heinrich, G.

AU - Bell, G. I.

AU - Naylor, S. L.

AU - Sakaguchi, A. Y.

N1 - Funding Information: We thank M. Yanagimachi for skilled technical assistance, E. Fisher and B. Russell for typing the manuscript, and B. Bowman for use of equipment and facilities. This study was supported by CA39186 from the National Cancer Institute (A.Y.S.); and Cancer Research from the Ministry of Education Science and Culture, and Society for Promotion of Cancer Research, Japan (M.C.Y.).

PY - 1985/9/30

Y1 - 1985/9/30

N2 - Insulin, parathyroid hormone, and calcitonin are polypeptide hormones that regulate important physiological processes in target tissues. Rat genes encoding each hormone were chromosomally assigned to rat chromosome 1. Both rats and mice have two insulin genes (I and II). However, in contrast to mice in which insulin I and II are asyntenic, rat insulin I and II were both localized to chromosome 1. This study identifies a conserved syntenic group on rat chromosome 1, and implies that mouse insulin I and II genes were chromosomally separated after rats and mice diverged 20-35 million years ago.

AB - Insulin, parathyroid hormone, and calcitonin are polypeptide hormones that regulate important physiological processes in target tissues. Rat genes encoding each hormone were chromosomally assigned to rat chromosome 1. Both rats and mice have two insulin genes (I and II). However, in contrast to mice in which insulin I and II are asyntenic, rat insulin I and II were both localized to chromosome 1. This study identifies a conserved syntenic group on rat chromosome 1, and implies that mouse insulin I and II genes were chromosomally separated after rats and mice diverged 20-35 million years ago.

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U2 - 10.1016/0006-291X(85)90214-1

DO - 10.1016/0006-291X(85)90214-1

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AN - SCOPUS:0022345739

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EP - 1180

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Genes for insulin I and II, parathyroid hormone, and calcitonin are on rat chromosome 1

Abstract

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