Generation of endoderm lineages from pluripotent stem cells

Xie Luo, Han Wang, Jake Leighton, Mara O'Sullivan, Pei Wang

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Definitive endoderm is the cellular precursor to respiratory- and digestive-related organs such as lungs, stomach, liver, pancreas and intestine. Endodermal lineage cells derived from pluripotent stem cells (PSCs) in vitro are a potentially unlimited resource for regenerative medicine. These cells are useful tools for studying the physiology, pathogenesis and medical therapies involving these tissues, and great progress has been achieved in PSCs differentiation protocols. In this review, we will focus on the most common and/or advanced differentiation strategies currently used in generating endodermal lineage cells from PSCs. A brief discussion about the effect of early definitive endoderm differentiation on the final development products will follow.

Original languageEnglish (US)
Pages (from-to)77-89
Number of pages13
JournalRegenerative Medicine
Issue number1
StatePublished - Jan 2017


  • definitive endoderm
  • embryonic stem cells
  • induced pluripotent stem cells
  • intestine
  • liver
  • lungs
  • pancreas
  • pluripotent stem cells
  • stomach
  • thyroid

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology


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