General properties of dendritic cell populations in cancer

Benjamin J. Daniel, Duane P. Jeansonne, Suzanne R. Thibodeaux, Tyler J. Curiel

Research output: Chapter in Book/Report/Conference proceedingChapter


Various, distinct populations of dendritic cells (DC) populate different normal, quiescent tissues in differing amounts, where they subserve a variety of functions generally for the benefit of the host. In cancers, the types, relative proportions, and functions of DC are altered, often to the detriment of the host. This chapter reviews the general issues related to imbalanced DC populations and their causes and dysfunctional consequences in the tumor microenvironment. Potential applications of this knowledge to novel anti-cancer immunotherapy strategies are outlined. Human and mouse disease models suitable for the study of tumor microenvironmental DC are discussed.

Original languageEnglish (US)
Title of host publicationDendritic Cells in Cancer
PublisherSpringer US
Number of pages11
ISBN (Print)9780387886107
StatePublished - 2009

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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