Gene structure of semenogelin I and II: The predominant proteins in human semen are encoded by two homologous genes on chromosome 20

Magnus Ulvsbäck, Claude Lazure, Hans Lilja, Nigel K. Spurr, Gopalrao V Velagaleti, Christiane Löffler, Ingo Hansmann, Åke Lundwall

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The genes for semenogelin I and II, the major protein constituents of the human seminal fluid, have been characterized by three overlapping clones in bacteriophage λ, encompassing 31.5 kilobases (kb) of genomic DNA The two genes are located 11.5 kb apart in the region q12-q13.1 on chromosome 20. Both genes are relatively compact, spanning only 2.7 and 3.1 kb, respectively. The transcription units are composed of three exons, of which the first encodes the signal peptide, the second encodes the secreted protein, while the third solely contains 3′-noncoding nucleotides. The nucleotide sequences exhibit a similarity of close to 90% in the exons and exceeding 80% in the introns and flanking nucleotides.

Original languageEnglish (US)
Pages (from-to)18080-18084
Number of pages5
JournalJournal of Biological Chemistry
Volume267
Issue number25
StatePublished - Sep 5 1992
Externally publishedYes

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Chromosomes, Human, Pair 20
Chromosomes
Semen
Nucleotides
Genes
Exons
Proteins
Bacteriophages
Transcription
Protein Sorting Signals
Introns
Clone Cells
Fluids
DNA

ASJC Scopus subject areas

  • Biochemistry

Cite this

Gene structure of semenogelin I and II : The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. / Ulvsbäck, Magnus; Lazure, Claude; Lilja, Hans; Spurr, Nigel K.; Velagaleti, Gopalrao V; Löffler, Christiane; Hansmann, Ingo; Lundwall, Åke.

In: Journal of Biological Chemistry, Vol. 267, No. 25, 05.09.1992, p. 18080-18084.

Research output: Contribution to journalArticle

Ulvsbäck, M, Lazure, C, Lilja, H, Spurr, NK, Velagaleti, GV, Löffler, C, Hansmann, I & Lundwall, Å 1992, 'Gene structure of semenogelin I and II: The predominant proteins in human semen are encoded by two homologous genes on chromosome 20', Journal of Biological Chemistry, vol. 267, no. 25, pp. 18080-18084.
Ulvsbäck, Magnus ; Lazure, Claude ; Lilja, Hans ; Spurr, Nigel K. ; Velagaleti, Gopalrao V ; Löffler, Christiane ; Hansmann, Ingo ; Lundwall, Åke. / Gene structure of semenogelin I and II : The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. In: Journal of Biological Chemistry. 1992 ; Vol. 267, No. 25. pp. 18080-18084.
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