Gene sets enrichment analysis of miRNA expression profile

Tzu Hung Hsiao, Hung I.Harry Chen, Patricia C. Sanchez-Diaz, Jaclyn Y. Hung, Yidong Chen, Yufei Huang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Alteration in expression levels of genes as well as their regulatory components, such as those levels of miRNAs in cancer cells will likely reflect in the enrichment of unique cellular functions and biological processes in their corresponding cell systems. By employing systems biology approaches, and instead of examining individual gene, we will directly and unambiguously identify the regulatory pathways and biological processes that are distinctive to specific disease states or responses to therapeutic treatment. In this study, we employ gene set enrichment analysis inspired method to explore the functional regulation of miRNAs. The analysis integrated a mathematic model that associates miRNAs to gene sets through miRNA target genes with a statistic test of enrichment to study the regulation change at a specific pathway. Different from conventional individual miRNA processing procedures, our method enables researchers to construct regulation hypothesis at pathway and functional levels.

Original languageEnglish (US)
Title of host publication2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
Pages449-454
Number of pages6
DOIs
StatePublished - Dec 1 2011
Event2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011 - Atlanta, GA, United States
Duration: Nov 12 2011Nov 15 2011

Publication series

Name2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011

Other

Other2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
CountryUnited States
CityAtlanta, GA
Period11/12/1111/15/11

Keywords

  • gene regulation
  • miRNA
  • pathway analysis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

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  • Cite this

    Hsiao, T. H., Chen, H. I. H., Sanchez-Diaz, P. C., Hung, J. Y., Chen, Y., & Huang, Y. (2011). Gene sets enrichment analysis of miRNA expression profile. In 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011 (pp. 449-454). [6112413] (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011). https://doi.org/10.1109/BIBMW.2011.6112413