Gene regulation by melatonin linked to epigenetic phenomena

Ahmet Korkmaz, Sergio Rosales-Corral, Russel J Reiter

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Many exogenous (e.g., toxins, chemicals, ultraviolet, cigarette smoke) and endogenous (e.g., hyperglycemia, dyslipidemia, cytokines, chemokines) agents disrupt the intracellular environment and result in a massive production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). The molecular damage that ROS/RNS induce is referred to as nitrooxidative stress. The cellular consequences of nitrooxidative stress include lipid peroxidation, protein oxidation and DNA damage. Additionally, ROS and RNS deplete cellular defenses and initiate inflammation. It is widely accepted that nitrooxidative stress and inflammation play important roles in the pathogenesis of a variety of human diseases and sequelae. Several processes are crucial to overcome the damaging cellular events caused by nitrooxidative stress, e.g., scavenging both ROS and RNS, induction of defense mechanisms and alleviating/suppressing inflammation are essential. Both endogenous and pharmacological concentrations of melatonin have long been known to play role in the direct scavenging of ROS and RNS as well as inducing antioxidant defense mechanisms and ameliorating inflammation. The current review summarizes research related to two major transcription factors that participate in these processes and summarizes how melatonin regulates antioxidant and pro-inflammatory genes via epigenetic on/off mechanisms.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalGene
Volume503
Issue number1
DOIs
StatePublished - Jul 15 2012

Fingerprint

Reactive Nitrogen Species
Melatonin
Epigenomics
Reactive Oxygen Species
Inflammation
Genes
Antioxidants
Dyslipidemias
Chemokines
Smoke
Tobacco Products
Hyperglycemia
Lipid Peroxidation
DNA Damage
Transcription Factors
Pharmacology
Cytokines
Research
Proteins

Keywords

  • Cytokines
  • Epigenetics
  • Free radicals
  • Melatonin
  • Oxidative stress
  • Transcription

ASJC Scopus subject areas

  • Genetics

Cite this

Gene regulation by melatonin linked to epigenetic phenomena. / Korkmaz, Ahmet; Rosales-Corral, Sergio; Reiter, Russel J.

In: Gene, Vol. 503, No. 1, 15.07.2012, p. 1-11.

Research output: Contribution to journalArticle

Korkmaz, Ahmet ; Rosales-Corral, Sergio ; Reiter, Russel J. / Gene regulation by melatonin linked to epigenetic phenomena. In: Gene. 2012 ; Vol. 503, No. 1. pp. 1-11.
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