Gene frequencies and genetic linkage disequilibrium for the HLA-linked genes Bf, C2, C4S, C4F, 21-hydroxylase deficiency, and glyoxalase I

G. J. O'Neill, M. S. Pollack, S. Y. Yang, L. S. Levine, M. I. New, B. Dupont

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The present investigation demonstrates that all the genes in close linkage with HLA show some degree of nonrandom association. The authors have failed to demonstrate that the GLO locus has significant associations to HLA, as previously described by Dausset et al. The data demonstrate that the demarcation between what they call HLA-determinants 'proper' on the one hand and HLA-linked coinhabitant genes on the other hand is presently based on concepts about the biologic function of HLA.

Original languageEnglish (US)
Pages (from-to)1713-1715
Number of pages3
JournalTransplantation Proceedings
Volume11
Issue number4
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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