Gene for parathyroid hormone-like peptide is on rat chromosome 2

G. N. Hendy; A. Y. Sakaguchi; T. Yasuda; D. K. Weber; L. M. Wang; M. C. Yoshida; D. Banville; D. Goltzman

doi:10.1016/S0006-291X(88)80285-7

Gene for parathyroid hormone-like peptide is on rat chromosome 2

G. N. Hendy
, A. Y. Sakaguchi
, T. Yasuda
, D. K. Weber
, L. M. Wang
, M. C. Yoshida
, D. Banville
, D. Goltzman

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Parathyroid hormone-like peptide (PLP) is thought to be a mediator of hypercalcemia in both human and rodent malignancies. A rat PLP cDNA was used as a hybridization probe in Southern blot analysis of DNAs isolated from a panel of rat-mouse somatic cell hybrids. The single-copy gene for PLP was assigned to rat chromosome 2, whereas the rat parathyroid hormone (PTH) gene has previously been assigned to rat chromosome 1. Consequently, despite significant amino-terminal homology between PLP and PTH the genes encoding these peptides in the rat as well as human species have discrete chromosomal localizations.

Original language	English (US)
Pages (from-to)	558-562
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	157
Issue number	2
DOIs	https://doi.org/10.1016/S0006-291X(88)80285-7
State	Published - Dec 15 1988

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/S0006-291X(88)80285-7

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@article{bf597da90e274e5bb6c8a05dbd49a42f,

title = "Gene for parathyroid hormone-like peptide is on rat chromosome 2",

abstract = "Parathyroid hormone-like peptide (PLP) is thought to be a mediator of hypercalcemia in both human and rodent malignancies. A rat PLP cDNA was used as a hybridization probe in Southern blot analysis of DNAs isolated from a panel of rat-mouse somatic cell hybrids. The single-copy gene for PLP was assigned to rat chromosome 2, whereas the rat parathyroid hormone (PTH) gene has previously been assigned to rat chromosome 1. Consequently, despite significant amino-terminal homology between PLP and PTH the genes encoding these peptides in the rat as well as human species have discrete chromosomal localizations.",

author = "Hendy, \{G. N.\} and Sakaguchi, \{A. Y.\} and T. Yasuda and Weber, \{D. K.\} and Wang, \{L. M.\} and Yoshida, \{M. C.\} and D. Banville and D. Goltzman",

note = "Funding Information: We thank Ms. KJerstine Kinaschuk and Mrs. Diane Allen for preparation of the manuscript. This study was supported by a grant from the National Cancer Institute of Canada, grants MT-5775 and MA-9315 from the Medical Research Council of Canada and Project Program Grant AG06872 National Institutes of Aging. GNH is a recipient of a Scholarship from the MRC of Canada.",

year = "1988",

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doi = "10.1016/S0006-291X(88)80285-7",

language = "English (US)",

volume = "157",

pages = "558--562",

journal = "Biochemical and Biophysical Research Communications",

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TY - JOUR

T1 - Gene for parathyroid hormone-like peptide is on rat chromosome 2

AU - Hendy, G. N.

AU - Sakaguchi, A. Y.

AU - Yasuda, T.

AU - Weber, D. K.

AU - Wang, L. M.

AU - Yoshida, M. C.

AU - Banville, D.

AU - Goltzman, D.

N1 - Funding Information: We thank Ms. KJerstine Kinaschuk and Mrs. Diane Allen for preparation of the manuscript. This study was supported by a grant from the National Cancer Institute of Canada, grants MT-5775 and MA-9315 from the Medical Research Council of Canada and Project Program Grant AG06872 National Institutes of Aging. GNH is a recipient of a Scholarship from the MRC of Canada.

PY - 1988/12/15

Y1 - 1988/12/15

N2 - Parathyroid hormone-like peptide (PLP) is thought to be a mediator of hypercalcemia in both human and rodent malignancies. A rat PLP cDNA was used as a hybridization probe in Southern blot analysis of DNAs isolated from a panel of rat-mouse somatic cell hybrids. The single-copy gene for PLP was assigned to rat chromosome 2, whereas the rat parathyroid hormone (PTH) gene has previously been assigned to rat chromosome 1. Consequently, despite significant amino-terminal homology between PLP and PTH the genes encoding these peptides in the rat as well as human species have discrete chromosomal localizations.

AB - Parathyroid hormone-like peptide (PLP) is thought to be a mediator of hypercalcemia in both human and rodent malignancies. A rat PLP cDNA was used as a hybridization probe in Southern blot analysis of DNAs isolated from a panel of rat-mouse somatic cell hybrids. The single-copy gene for PLP was assigned to rat chromosome 2, whereas the rat parathyroid hormone (PTH) gene has previously been assigned to rat chromosome 1. Consequently, despite significant amino-terminal homology between PLP and PTH the genes encoding these peptides in the rat as well as human species have discrete chromosomal localizations.

UR - https://www.scopus.com/pages/publications/0024262746

UR - https://www.scopus.com/pages/publications/0024262746#tab=citedBy

U2 - 10.1016/S0006-291X(88)80285-7

DO - 10.1016/S0006-291X(88)80285-7

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AN - SCOPUS:0024262746

SN - 0006-291X

VL - 157

SP - 558

EP - 562

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Gene for parathyroid hormone-like peptide is on rat chromosome 2

Abstract

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