Gene for parathyroid hormone-like peptide is on rat chromosome 2

G. N. Hendy, A. Y. Sakaguchi, T. Yasuda, D. K. Weber, L. M. Wang, M. C. Yoshida, D. Banville, D. Goltzman

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Parathyroid hormone-like peptide (PLP) is thought to be a mediator of hypercalcemia in both human and rodent malignancies. A rat PLP cDNA was used as a hybridization probe in Southern blot analysis of DNAs isolated from a panel of rat-mouse somatic cell hybrids. The single-copy gene for PLP was assigned to rat chromosome 2, whereas the rat parathyroid hormone (PTH) gene has previously been assigned to rat chromosome 1. Consequently, despite significant amino-terminal homology between PLP and PTH the genes encoding these peptides in the rat as well as human species have discrete chromosomal localizations.

Original languageEnglish (US)
Pages (from-to)558-562
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume157
Issue number2
DOIs
StatePublished - Dec 15 1988

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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