The single-copy parathyroid hormone-like peplide gene (Ptlilh) was assigned to mouse chromosome 6 using a rat PTHLH cDNA as hybridization probe in Southern blot analysis of DN As isolated from a panel of mouse x Chinese hamster cell hybrids. The mouse parathyroid hormone gene (Prh) has previously been assigned to mouse chromosome 7 and the PTHLH and PTH genes have also been shown to be on different chromosomes in human and rat. Therefore, despite significant amino-terminal sequence homology between the PTHLH and PTH peptides. as well as similarities in the structural organization of the human PTH LH and PTH genes, the genes encoding these peptides have discrete chromosomal locations in the mouse, rat, and man.
ASJC Scopus subject areas
- Molecular Biology