Gene flow of unique sequences between Mus musculus domesticus and Mus spretus

Rhonda Greene-Till, Yingping Zhao, Stephen C. Hardies

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Allelic diversity has been examined from a variety of Mus musculus subspecies and Mus spretus strains by sequencing at a 453-bp unique sequence locus. One M. m. domesticus classic inbred strain, C57BL/KsJ, contained a sequence identical to that in the M. spretus wild-derived inbred strain SEG, and other wild M. spretus isolates. Such a result should have been precluded by the expected divergence between the species unless there has been interspecies gene flow. Examination of C57BL/KsJ for M. spretus-specific repetitive sequences shows that it is neither a misidentified spretus strain nor a domesticus/spretus hybrid. Thus, in addition to the previously reported presence of small amounts of Mus spretus-specific repetitive DNA in M. m. domesticus, there is a detectable flow of unique sequence between the two species. There was also ancestral polymorphism observed among the spretus alleles. The difficulty of distinguishing ancestral polymorphism from horizontal transfer is discussed.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalMammalian Genome
Issue number3
StatePublished - 2000

ASJC Scopus subject areas

  • Genetics


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