Gene expression profile in multiple sclerosis patients and healthy controls: Identifying pathways relevant to disease

Roberto Bomprezzi, Markus Ringnér, Seungchan Kim, Michael L. Bittner, Javed Khan, Yidong Chen, Abdel Elkahloun, Aimee Yu, Bibiana Bielekova, Paul S. Meltzer, Roland Martin, Henry F. McFarland, Jeffrey M. Trent

Research output: Contribution to journalArticle

161 Scopus citations

Abstract

Multiple sclerosis (MS) and other T cell-mediated autoimmune diseases develop in individuals carrying a complex susceptibility trait, probably following exposure to various environmental triggers. Owing to the presumed weak influence of single genes on disease predisposition and the recognized genetic heterogeneity of autoimmune disorders in humans, candidate gene searches in MS have been difficult. In an attempt to identify molecular markers indicative of disease status rather than susceptibility genes for MS, we show that gene expression profiling of peripheral blood mononuclear cells by cDNA microarrays can distinguish MS patients from healthy controls. Our findings support the concept that the activation of autoreactive T cells is of primary importance for this complex organ-specific disorder and prompt further investigations on gene expression in peripheral blood cells aimed at characterizing disease phenotypes.

Original languageEnglish (US)
Pages (from-to)2191-2199
Number of pages9
JournalHuman molecular genetics
Volume12
Issue number17
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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    Bomprezzi, R., Ringnér, M., Kim, S., Bittner, M. L., Khan, J., Chen, Y., Elkahloun, A., Yu, A., Bielekova, B., Meltzer, P. S., Martin, R., McFarland, H. F., & Trent, J. M. (2003). Gene expression profile in multiple sclerosis patients and healthy controls: Identifying pathways relevant to disease. Human molecular genetics, 12(17), 2191-2199. https://doi.org/10.1093/hmg/ddg221