Gene-expression differences in peripheral blood between lithium responders and non-responders in the Lithium Treatment-Moderate dose Use Study (LiTMUS)

R. D. Beech, J. J. Leffert, A. Lin, L. G. Sylvia, S. Umlauf, S. Mane, H. Zhao, C. Bowden, J. R. Calabrese, E. S. Friedman, T. A. Ketter, D. V. Iosifescu, N. A. Reilly-Harrington, M. Ostacher, M. E. Thase, A. Nierenberg

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

This study was designed to identify genes whose expression in peripheral blood may serve as early markers for treatment response to lithium (Li) in patients with bipolar disorder. Although changes in peripheral blood gene-expression may not relate directly to mood symptoms, differences in treatment response at the biochemical level may underlie some of the heterogeneity in clinical response to Li. Subjects were randomized to treatment with (n=28) or without (n=32) Li. Peripheral blood gene-expression was measured before and 1month after treatment initiation, and treatment response was assessed after 6 months. In subjects treated with Li, 62 genes were differentially regulated in treatment responders and non-responders. Of these, BCL2L1 showed the greatest difference between Li responders and non-responders. These changes were specific to Li responders (n=9), and were not seen in Li non-responders or patients treated without Li, suggesting that they may have specific roles in treatment response to Li.

Original languageEnglish (US)
Pages (from-to)182-191
Number of pages10
JournalPharmacogenomics Journal
Volume14
Issue number2
DOIs
StatePublished - Apr 2014

Keywords

  • BCL2L1
  • Bipolar disorder
  • Gene expression
  • Lithium-response
  • Microarray

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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