Gene expression defines natural changes in mammalian lifespan

Alexey A. Fushan, Anton A. Turanov, Sang Goo Lee, Eun Bae Kim, Alexei V. Lobanov, Sun Hee Yim, Rochelle Buffenstein, Sang Rae Lee, Kyu Tae Chang, Hwanseok Rhee, Jong So Kim, Kap Seok Yang, Vadim N. Gladyshev

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


Mammals differ more than 100-fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages. To understand the relationship between lifespan and variation in gene expression, we carried out RNA-seq-based gene expression analyses of liver, kidney, and brain of 33 diverse species of mammals. Our analysis uncovered parallel evolution of gene expression and lifespan, as well as the associated life-history traits, and identified the processes and pathways involved. These findings provide direct insights into how nature reversibly adjusts lifespan and other traits during adaptive radiation of lineages.

Original languageEnglish (US)
Pages (from-to)352-365
Number of pages14
JournalAging cell
Issue number3
StatePublished - Jun 1 2015


  • Aging
  • Gene expression
  • Life-history traits
  • Lifespan
  • Mammals

ASJC Scopus subject areas

  • Aging
  • Cell Biology


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