Gene copy number and malaria biology

Tim J.C. Anderson, Jigar Patel, Michael T. Ferdig

    Research output: Contribution to journalReview articlepeer-review

    27 Scopus citations

    Abstract

    Alteration in gene copy number provides a simple way to change expression levels and alter phenotype. This was fully appreciated by bacteriologists more than 25 years ago, but the extent and implications of copy number polymorphism (CNP) have only recently become apparent in other organisms. New methods demonstrate the ubiquity of CNPs in eukaryotes and their medical importance in humans. CNP is also widespread in the Plasmodium falciparum genome and has an important and underappreciated role in determining phenotype. In this review, we summarize the distribution of CNP, its evolutionary dynamics within populations, its functional importance and its mode of evolution.

    Original languageEnglish (US)
    Pages (from-to)336-343
    Number of pages8
    JournalTrends in Parasitology
    Volume25
    Issue number7
    DOIs
    StatePublished - Jul 1 2009

    ASJC Scopus subject areas

    • Parasitology
    • Infectious Diseases

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