Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar

Mallika Imwong, Sasithon Pukrittayakamee, Wirichada Pongtavornpinyo, Supatchara Nakeesathit, Shalini Nair, Paul Newton, Francois Nosten, Timothy J C Anderson, Arjen Dondorp, Nicholas P J Day, Nicholas J. White

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found.

Original languageEnglish (US)
Pages (from-to)2657-2659
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number7
DOIs
StatePublished - Jul 2008
Externally publishedYes

Fingerprint

Laos
Myanmar
MDR Genes
Plasmodium vivax
Gene Amplification
Thailand
Mefloquine
Southeastern Asia
Real-Time Polymerase Chain Reaction
Pressure
Mutation

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Imwong, M., Pukrittayakamee, S., Pongtavornpinyo, W., Nakeesathit, S., Nair, S., Newton, P., ... White, N. J. (2008). Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar. Antimicrobial Agents and Chemotherapy, 52(7), 2657-2659. https://doi.org/10.1128/AAC.01459-07

Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar. / Imwong, Mallika; Pukrittayakamee, Sasithon; Pongtavornpinyo, Wirichada; Nakeesathit, Supatchara; Nair, Shalini; Newton, Paul; Nosten, Francois; Anderson, Timothy J C; Dondorp, Arjen; Day, Nicholas P J; White, Nicholas J.

In: Antimicrobial Agents and Chemotherapy, Vol. 52, No. 7, 07.2008, p. 2657-2659.

Research output: Contribution to journalArticle

Imwong, M, Pukrittayakamee, S, Pongtavornpinyo, W, Nakeesathit, S, Nair, S, Newton, P, Nosten, F, Anderson, TJC, Dondorp, A, Day, NPJ & White, NJ 2008, 'Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar', Antimicrobial Agents and Chemotherapy, vol. 52, no. 7, pp. 2657-2659. https://doi.org/10.1128/AAC.01459-07
Imwong, Mallika ; Pukrittayakamee, Sasithon ; Pongtavornpinyo, Wirichada ; Nakeesathit, Supatchara ; Nair, Shalini ; Newton, Paul ; Nosten, Francois ; Anderson, Timothy J C ; Dondorp, Arjen ; Day, Nicholas P J ; White, Nicholas J. / Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar. In: Antimicrobial Agents and Chemotherapy. 2008 ; Vol. 52, No. 7. pp. 2657-2659.
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