Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar

Mallika Imwong, Sasithon Pukrittayakamee, Wirichada Pongtavornpinyo, Supatchara Nakeesathit, Shalini Nair, Paul Newton, Francois Nosten, Timothy J.C. Anderson, Arjen Dondorp, Nicholas P.J. Day, Nicholas J. White

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found.

Original languageEnglish (US)
Pages (from-to)2657-2659
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume52
Issue number7
DOIs
StatePublished - Jul 2008
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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