Abstract
Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2657-2659 |
| Number of pages | 3 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 52 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2008 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar. / Imwong, Mallika; Pukrittayakamee, Sasithon; Pongtavornpinyo, Wirichada; Nakeesathit, Supatchara; Nair, Shalini; Newton, Paul; Nosten, Francois; Anderson, Timothy J C; Dondorp, Arjen; Day, Nicholas P J; White, Nicholas J.
In: Antimicrobial Agents and Chemotherapy, Vol. 52, No. 7, 07.2008, p. 2657-2659.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar
AU - Imwong, Mallika
AU - Pukrittayakamee, Sasithon
AU - Pongtavornpinyo, Wirichada
AU - Nakeesathit, Supatchara
AU - Nair, Shalini
AU - Newton, Paul
AU - Nosten, Francois
AU - Anderson, Timothy J C
AU - Dondorp, Arjen
AU - Day, Nicholas P J
AU - White, Nicholas J.
PY - 2008/7
Y1 - 2008/7
N2 - Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found.
AB - Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found.
UR - http://www.scopus.com/inward/record.url?scp=46249096629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46249096629&partnerID=8YFLogxK
U2 - 10.1128/AAC.01459-07
DO - 10.1128/AAC.01459-07
M3 - Article
VL - 52
SP - 2657
EP - 2659
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 7
ER -