Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar

Mallika Imwong; Sasithon Pukrittayakamee; Wirichada Pongtavornpinyo; Supatchara Nakeesathit; Shalini Nair; Paul Newton; Francois Nosten; Timothy J.C. Anderson; Arjen Dondorp; Nicholas P.J. Day; Nicholas J. White

doi:10.1128/AAC.01459-07

Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar

Mallika Imwong, Sasithon Pukrittayakamee, Wirichada Pongtavornpinyo, Supatchara Nakeesathit, Shalini Nair, Paul Newton, Francois Nosten, Timothy J.C. Anderson, Arjen Dondorp, Nicholas P.J. Day, Nicholas J. White

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found.

Original language	English (US)
Pages (from-to)	2657-2659
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	52
Issue number	7
DOIs	https://doi.org/10.1128/AAC.01459-07
State	Published - Jul 2008

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Imwong, M., Pukrittayakamee, S., Pongtavornpinyo, W., Nakeesathit, S., Nair, S., Newton, P., Nosten, F., Anderson, T. J. C., Dondorp, A., Day, N. P. J., & White, N. J. (2008). Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar. Antimicrobial agents and chemotherapy, 52(7), 2657-2659. https://doi.org/10.1128/AAC.01459-07

Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar. / Imwong, Mallika; Pukrittayakamee, Sasithon; Pongtavornpinyo, Wirichada; Nakeesathit, Supatchara; Nair, Shalini; Newton, Paul; Nosten, Francois; Anderson, Timothy J.C.; Dondorp, Arjen; Day, Nicholas P.J.; White, Nicholas J.

In: Antimicrobial agents and chemotherapy, Vol. 52, No. 7, 07.2008, p. 2657-2659.

Research output: Contribution to journal › Article › peer-review

Imwong, M, Pukrittayakamee, S, Pongtavornpinyo, W, Nakeesathit, S, Nair, S, Newton, P, Nosten, F, Anderson, TJC, Dondorp, A, Day, NPJ & White, NJ 2008, 'Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar', Antimicrobial agents and chemotherapy, vol. 52, no. 7, pp. 2657-2659. https://doi.org/10.1128/AAC.01459-07

Imwong, Mallika ; Pukrittayakamee, Sasithon ; Pongtavornpinyo, Wirichada ; Nakeesathit, Supatchara ; Nair, Shalini ; Newton, Paul ; Nosten, Francois ; Anderson, Timothy J.C. ; Dondorp, Arjen ; Day, Nicholas P.J. ; White, Nicholas J. / Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar. In: Antimicrobial agents and chemotherapy. 2008 ; Vol. 52, No. 7. pp. 2657-2659.

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