Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar

Mallika Imwong, Sasithon Pukrittayakamee, Wirichada Pongtavornpinyo, Supatchara Nakeesathit, Shalini Nair, Paul Newton, Francois Nosten, Timothy J.C. Anderson, Arjen Dondorp, Nicholas P.J. Day, Nicholas J. White

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    55 Scopus citations

    Abstract

    Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found.

    Original languageEnglish (US)
    Pages (from-to)2657-2659
    Number of pages3
    JournalAntimicrobial agents and chemotherapy
    Volume52
    Issue number7
    DOIs
    StatePublished - Jul 1 2008

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    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)
    • Infectious Diseases

    Cite this

    Imwong, M., Pukrittayakamee, S., Pongtavornpinyo, W., Nakeesathit, S., Nair, S., Newton, P., Nosten, F., Anderson, T. J. C., Dondorp, A., Day, N. P. J., & White, N. J. (2008). Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar. Antimicrobial agents and chemotherapy, 52(7), 2657-2659. https://doi.org/10.1128/AAC.01459-07