TY - JOUR
T1 - Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar
AU - Imwong, Mallika
AU - Pukrittayakamee, Sasithon
AU - Pongtavornpinyo, Wirichada
AU - Nakeesathit, Supatchara
AU - Nair, Shalini
AU - Newton, Paul
AU - Nosten, Francois
AU - Anderson, Timothy J.C.
AU - Dondorp, Arjen
AU - Day, Nicholas P.J.
AU - White, Nicholas J.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/7
Y1 - 2008/7
N2 - Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found.
AB - Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found.
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U2 - 10.1128/AAC.01459-07
DO - 10.1128/AAC.01459-07
M3 - Article
C2 - 18443118
AN - SCOPUS:46249096629
VL - 52
SP - 2657
EP - 2659
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 7
ER -