Gender dimorphisms in progenitor and stem cell function in cardiovascular disease

Jeremy L. Herrmann, Aaron M. Abarbanell, Brent R. Weil, Mariuxi C. Manukyan, Jeffrey A. Poynter, Yue Wang, Arthur C. Coffey, Daniel R. Meldrum

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Differences in cardiovascular disease outcomes between men and women have long been recognized and attributed, in part, to gender and sex steroids. Gender dimorphisms also exist with respect to the roles of progenitor and stem cells in post-ischemic myocardial and endothelial repair and regeneration. Understanding how these cells are influenced by donor gender and the recipient hormonal milieu may enable researchers to further account for the gender-related disparities in clinical outcomes as well as utilize the beneficial effects of these hormones to optimize transplanted cell function and survival. This review discusses (1) the cardiovascular effects of sex steroids (specifically estradiol and testosterone); (2) the therapeutic potentials of endothelial progenitor cells, mesenchymal stem cells, and embryonic stem cells; and (3) the direct effect of sex steroids on these cell types.

Original languageEnglish (US)
Pages (from-to)103-113
Number of pages11
JournalJournal of Cardiovascular Translational Research
Issue number2
StatePublished - Apr 2010
Externally publishedYes


  • Cardiovascular disease
  • Gender differences
  • Progenitor cells
  • Sex steroids
  • Stem cell therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)
  • Genetics
  • Molecular Medicine
  • Pharmaceutical Science


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