Gender differences in the enhanced vulnerability of BDNF+/ mice to mild stress

Tushar Advani, Wouter Koek, Julie G. Hensler

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Two mild stress paradigms were used in the present study: acute (i.e. three injections of saline over 24 h) and subchronic (i.e. single daily injection of saline for 7 d). These mild stress procedures did not alter the behaviour of wild-type mice in the forced swim test. However, male BDNF+/ mice exhibited increased immobility in the forced swim test after mild stress. This genotypic difference in stress responsivity was also evident in plasma corticosterone levels after a single injection of saline. The behaviour of female mice of either genotype was not altered by mild stress, and there was no genotypic difference in the corticosterone response of female mice to a single saline injection. Male BDNF+/ mice should be a useful model in which to examine behavioural and neurochemical consequences of interactions among genetic and environmental factors implicated in stress-related affective disorders, such as major depression.

Original languageEnglish (US)
Pages (from-to)583-588
Number of pages6
JournalInternational Journal of Neuropsychopharmacology
Volume12
Issue number5
DOIs
StatePublished - Jun 2009

Keywords

  • Brain-derived neurotrophic factor
  • Corticosterone
  • Forced swim test

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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