Abstract
The Genetic Analysis Workshop (GAW) 12 simulated data involves a common disease defined by imposing a threshold on a quantitative liability distribution. Associated with the disease are five quantitative risk factors, a quantitative environmental exposure, and a dichotomous environmental variable. Age at disease onset and household membership were also simulated. Genotype data, including 2,855 microsatellites on 22 autosomes, were simulated for 1,497 individuals in 23 families. Phenotype data and sequence data for seven candidate genes were provided for 1,000 of these indiviudals who were "living" and available for study. Data were simulated for 50 replicate samples in each of two populations, a general population and a population isolate formed from a small group of founders.
| Original language | English (US) |
|---|---|
| Journal | Genetic Epidemiology |
| Volume | 21 |
| Issue number | SUPPL. 1 |
| State | Published - 2001 |
| Externally published | Yes |
Fingerprint
Keywords
- Population isolate
- Quantitative trait
- Simulation
ASJC Scopus subject areas
- Genetics(clinical)
- Epidemiology
Cite this
GAW12 : Simulated genome scan, sequence, and family data for a common disease. / Almasy, L.; Terwilliger, J. D.; Nielsen, D.; Dyer, T. D.; Zaykin, D.; Blangero, J.
In: Genetic Epidemiology, Vol. 21, No. SUPPL. 1, 2001.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - GAW12
T2 - Simulated genome scan, sequence, and family data for a common disease
AU - Almasy, L.
AU - Terwilliger, J. D.
AU - Nielsen, D.
AU - Dyer, T. D.
AU - Zaykin, D.
AU - Blangero, J.
PY - 2001
Y1 - 2001
N2 - The Genetic Analysis Workshop (GAW) 12 simulated data involves a common disease defined by imposing a threshold on a quantitative liability distribution. Associated with the disease are five quantitative risk factors, a quantitative environmental exposure, and a dichotomous environmental variable. Age at disease onset and household membership were also simulated. Genotype data, including 2,855 microsatellites on 22 autosomes, were simulated for 1,497 individuals in 23 families. Phenotype data and sequence data for seven candidate genes were provided for 1,000 of these indiviudals who were "living" and available for study. Data were simulated for 50 replicate samples in each of two populations, a general population and a population isolate formed from a small group of founders.
AB - The Genetic Analysis Workshop (GAW) 12 simulated data involves a common disease defined by imposing a threshold on a quantitative liability distribution. Associated with the disease are five quantitative risk factors, a quantitative environmental exposure, and a dichotomous environmental variable. Age at disease onset and household membership were also simulated. Genotype data, including 2,855 microsatellites on 22 autosomes, were simulated for 1,497 individuals in 23 families. Phenotype data and sequence data for seven candidate genes were provided for 1,000 of these indiviudals who were "living" and available for study. Data were simulated for 50 replicate samples in each of two populations, a general population and a population isolate formed from a small group of founders.
KW - Population isolate
KW - Quantitative trait
KW - Simulation
UR - http://www.scopus.com/inward/record.url?scp=0034800188&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034800188&partnerID=8YFLogxK
M3 - Article
C2 - 11793693
AN - SCOPUS:0034800188
VL - 21
JO - Genetic Epidemiology
JF - Genetic Epidemiology
SN - 0741-0395
IS - SUPPL. 1
ER -