GAW12: Simulated genome scan, sequence, and family data for a common disease

L. Almasy; J. D. Terwilliger; D. Nielsen; T. D. Dyer; D. Zaykin; J. Blangero

doi:10.1002/gepi.2001.21.s1.s332

GAW12: Simulated genome scan, sequence, and family data for a common disease

L. Almasy, J. D. Terwilliger, D. Nielsen, T. D. Dyer, D. Zaykin, J. Blangero

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The Genetic Analysis Workshop (GAW) 12 simulated data involves a common disease defined by imposing a threshold on a quantitative liability distribution. Associated with the disease are five quantitative risk factors, a quantitative environmental exposure, and a dichotomous environmental variable. Age at disease onset and household membership were also simulated. Genotype data, including 2,855 microsatellites on 22 autosomes, were simulated for 1,497 individuals in 23 families. Phenotype data and sequence data for seven candidate genes were provided for 1,000 of these indiviudals who were "living" and available for study. Data were simulated for 50 replicate samples in each of two populations, a general population and a population isolate formed from a small group of founders.

Original language	English (US)
Pages (from-to)	S332-S338
Journal	Genetic epidemiology
Volume	21
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1002/gepi.2001.21.s1.s332
State	Published - 2001

Keywords

Population isolate
Quantitative trait
Simulation

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

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10.1002/gepi.2001.21.s1.s332

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AU - Zaykin, D.

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GAW12: Simulated genome scan, sequence, and family data for a common disease

Abstract

Keywords

ASJC Scopus subject areas

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