GAW12: Simulated genome scan, sequence, and family data for a common disease

L. Almasy, J. D. Terwilliger, D. Nielsen, T. D. Dyer, D. Zaykin, J. Blangero

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The Genetic Analysis Workshop (GAW) 12 simulated data involves a common disease defined by imposing a threshold on a quantitative liability distribution. Associated with the disease are five quantitative risk factors, a quantitative environmental exposure, and a dichotomous environmental variable. Age at disease onset and household membership were also simulated. Genotype data, including 2,855 microsatellites on 22 autosomes, were simulated for 1,497 individuals in 23 families. Phenotype data and sequence data for seven candidate genes were provided for 1,000 of these indiviudals who were "living" and available for study. Data were simulated for 50 replicate samples in each of two populations, a general population and a population isolate formed from a small group of founders.

Original languageEnglish (US)
JournalGenetic Epidemiology
Volume21
Issue numberSUPPL. 1
StatePublished - 2001
Externally publishedYes

Fingerprint

Genome
Population
Environmental Exposure
Age of Onset
Microsatellite Repeats
Genotype
Phenotype
Education
Genes

Keywords

  • Population isolate
  • Quantitative trait
  • Simulation

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Almasy, L., Terwilliger, J. D., Nielsen, D., Dyer, T. D., Zaykin, D., & Blangero, J. (2001). GAW12: Simulated genome scan, sequence, and family data for a common disease. Genetic Epidemiology, 21(SUPPL. 1).

GAW12 : Simulated genome scan, sequence, and family data for a common disease. / Almasy, L.; Terwilliger, J. D.; Nielsen, D.; Dyer, T. D.; Zaykin, D.; Blangero, J.

In: Genetic Epidemiology, Vol. 21, No. SUPPL. 1, 2001.

Research output: Contribution to journalArticle

Almasy, L, Terwilliger, JD, Nielsen, D, Dyer, TD, Zaykin, D & Blangero, J 2001, 'GAW12: Simulated genome scan, sequence, and family data for a common disease', Genetic Epidemiology, vol. 21, no. SUPPL. 1.
Almasy L, Terwilliger JD, Nielsen D, Dyer TD, Zaykin D, Blangero J. GAW12: Simulated genome scan, sequence, and family data for a common disease. Genetic Epidemiology. 2001;21(SUPPL. 1).
Almasy, L. ; Terwilliger, J. D. ; Nielsen, D. ; Dyer, T. D. ; Zaykin, D. ; Blangero, J. / GAW12 : Simulated genome scan, sequence, and family data for a common disease. In: Genetic Epidemiology. 2001 ; Vol. 21, No. SUPPL. 1.
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