TY - JOUR
T1 - GAW10
T2 - Simulated family data for a common oligogenic disease with quantitative risk factors
AU - MacCluer, Jean W.
AU - Blangero, John
AU - Dyer, Thomas D.
AU - Speer, Marcy C.
PY - 1997
Y1 - 1997
N2 - GAW10 Problem 2 involves a simulated common disease defined by imposing a threshold, T, on a quantitative trait, Q1. Every individual with a value of Q1 ≤ T (where T = 40) is defined as affected. Also thought to be associated with the disease as intervening variables are four other quantitative traits (Q2, Q3, Q4, and Q5) and an environmental factor (EF). Each individual has genotypes for 367 highly polymorphic markers on 10 chromosomes. The tasks for GAW10 were to characterize the genetic and environmental contribution to Q1 (and the disease), Q2, Q3, Q4 and Q5, and to localize any single genes that have detectable effects. Multiple replicates provided an opportunity to address questions of power and false positive rates.
AB - GAW10 Problem 2 involves a simulated common disease defined by imposing a threshold, T, on a quantitative trait, Q1. Every individual with a value of Q1 ≤ T (where T = 40) is defined as affected. Also thought to be associated with the disease as intervening variables are four other quantitative traits (Q2, Q3, Q4, and Q5) and an environmental factor (EF). Each individual has genotypes for 367 highly polymorphic markers on 10 chromosomes. The tasks for GAW10 were to characterize the genetic and environmental contribution to Q1 (and the disease), Q2, Q3, Q4 and Q5, and to localize any single genes that have detectable effects. Multiple replicates provided an opportunity to address questions of power and false positive rates.
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U2 - 10.1002/(SICI)1098-2272(1997)14:6<737::AID-GEPI29>3.0.CO;2-Q
DO - 10.1002/(SICI)1098-2272(1997)14:6<737::AID-GEPI29>3.0.CO;2-Q
M3 - Article
C2 - 9433570
AN - SCOPUS:0031454584
SN - 0741-0395
VL - 14
SP - 737
EP - 742
JO - Genetic Epidemiology
JF - Genetic Epidemiology
IS - 6
ER -