Gastroesophageal reflux disease in baboons (Papio sp.): A new animal model

E. J. Glover, M. M. Leland, E. J. Dick, G. B. Hubbard

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background: Gastroesophageal reflux disease (GERD) is increasingly prevalent in the human population. Current animal models require surgical or other manipulation to produce symptoms. An animal model that exhibits spontaneous GERD would provide the opportunity for much-needed research examining the susceptibility, diagnosis, and treatment of GERD. Methods: Eight baboons (Papio hamadryas sp.) were diagnosed with GERD histopathologically using biopsies or postmortem tissues. Results: The disease was characterized by a spectrum of symptoms comparable with that found in the human population. Some subjects had no gross signs of clinical disease, but were diagnosed by histopathological examination. Almost all subjects presented with at least one clinical sign of the disease. Regurgitation was the most common. Conclusions: The baboon may be a superior animal model for GERD research because it is a naturally occurring model and is anatomically and physiologically similar to humans.

Original languageEnglish (US)
Pages (from-to)18-25
Number of pages8
JournalJournal of medical primatology
Volume37
Issue number1
DOIs
StatePublished - Feb 1 2008
Externally publishedYes

Keywords

  • Esophagus
  • Gastroesophageal reflux disease
  • Non-human primate
  • Regurgitation
  • Stress

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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