Gastric Inhibitory Polypeptide: Response to Oral Glucose After Vagotomy and Pyloroplasty

Neil R. Thomford, Kenneth R. Sirinek, Samuel E. Crockett, Ernest L. Mazzaferri, Samuel Cataland

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Gastric inhibitory polypeptide (GIP), immunoreactive insulin (IRI), and glucose levels in response to orally administered glucose were determined in ten patients with vagotomy and pyloroplasty (V&P) and in 21 normal subjects. The V&P patients had the expected early and exaggerated increase in mean serum glucose with a subsequent decline to a level below fasting. The early mean GIP response was similarly elevated and paralleled the glucose response. The early mean serum IRI of V&P patients was greater than that of normal subjects, but only at 30 minutes was the difference statistically significant (P<.01). Since GIP is known to be insulinotropic, the results of this study suggest that its role in the enteroinsular axis is magnified after V&P. The GIP may be in part responsible for the postprandial hypoglycemia recognized clinically as the “late phase” of the dumping syndrome.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalArchives of Surgery
Issue number2
StatePublished - Aug 1974
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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