Abstract
Mexican Americans, a group at high risk for type II diabetes mellitus, have higher postprandial insulin and glucose levels when compared to non-Hispanic whites. A rapid rate of gastric emptying contributes to an increased rate of nutrient absorption and subsequent greater elevation of postprandial glucose and insulin levels. A more rapid rate of gastric emptying and hyperinsulinemia have been observed in patients with recently diagnosed type II diabetes mellitus. In this study, we examined whether Mexican Americans have a more rapid rate of gastric emptying than non-Hispanic whites. Gastric emptying studies were performed on 32 nondiabetic Mexican Americans and on 31 nondiabetic non-Hispanic whites. The rate of gastric emptying following a liquid glucose meal was measured. Serum insulin, plasma glucose, and GIP levels were measured in fasting and postprandial blood samples collected at 15-min intervals for 2 hr. Adjusting for age, body mass index, and gender, the gastric half-emptying time of a glucose meal was significantly (P<0.05) more rapid for the Mexican American subjects (56.5±3.4 min) compared to the non-Hispanic white subjects (66.4±3.5 min). Nondiabetic Mexican Americans empty a liquid glucose meal more rapidly from their stomachs than nondiabetic non-Hispanic whites. Rapid gastric emptying is associated with hyperinsulinemia as a normal physiologic response to increased nutrient availability. The rapid gastric emptying observed in nondiabetic Mexican Americans is associated with hyperinsulinemia and could be a contributing factor for the increased risk of obesity and type II diabetes in this population.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 624-630 |
| Number of pages | 7 |
| Journal | Digestive Diseases and Sciences |
| Volume | 40 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1995 |
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Keywords
- diabetes mellitus
- gastric emptying
- hyperinsulinemia
- Mexican Americans
ASJC Scopus subject areas
- Gastroenterology
Cite this
Gastric emptying in Mexican Americans compared to non-Hispanic whites. / Schwartz, Joyce G.; Alex McMahan, C.; Green, Gary M.; Phillips, William T.
In: Digestive Diseases and Sciences, Vol. 40, No. 3, 03.1995, p. 624-630.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gastric emptying in Mexican Americans compared to non-Hispanic whites
AU - Schwartz, Joyce G.
AU - Alex McMahan, C.
AU - Green, Gary M.
AU - Phillips, William T
PY - 1995/3
Y1 - 1995/3
N2 - Mexican Americans, a group at high risk for type II diabetes mellitus, have higher postprandial insulin and glucose levels when compared to non-Hispanic whites. A rapid rate of gastric emptying contributes to an increased rate of nutrient absorption and subsequent greater elevation of postprandial glucose and insulin levels. A more rapid rate of gastric emptying and hyperinsulinemia have been observed in patients with recently diagnosed type II diabetes mellitus. In this study, we examined whether Mexican Americans have a more rapid rate of gastric emptying than non-Hispanic whites. Gastric emptying studies were performed on 32 nondiabetic Mexican Americans and on 31 nondiabetic non-Hispanic whites. The rate of gastric emptying following a liquid glucose meal was measured. Serum insulin, plasma glucose, and GIP levels were measured in fasting and postprandial blood samples collected at 15-min intervals for 2 hr. Adjusting for age, body mass index, and gender, the gastric half-emptying time of a glucose meal was significantly (P<0.05) more rapid for the Mexican American subjects (56.5±3.4 min) compared to the non-Hispanic white subjects (66.4±3.5 min). Nondiabetic Mexican Americans empty a liquid glucose meal more rapidly from their stomachs than nondiabetic non-Hispanic whites. Rapid gastric emptying is associated with hyperinsulinemia as a normal physiologic response to increased nutrient availability. The rapid gastric emptying observed in nondiabetic Mexican Americans is associated with hyperinsulinemia and could be a contributing factor for the increased risk of obesity and type II diabetes in this population.
AB - Mexican Americans, a group at high risk for type II diabetes mellitus, have higher postprandial insulin and glucose levels when compared to non-Hispanic whites. A rapid rate of gastric emptying contributes to an increased rate of nutrient absorption and subsequent greater elevation of postprandial glucose and insulin levels. A more rapid rate of gastric emptying and hyperinsulinemia have been observed in patients with recently diagnosed type II diabetes mellitus. In this study, we examined whether Mexican Americans have a more rapid rate of gastric emptying than non-Hispanic whites. Gastric emptying studies were performed on 32 nondiabetic Mexican Americans and on 31 nondiabetic non-Hispanic whites. The rate of gastric emptying following a liquid glucose meal was measured. Serum insulin, plasma glucose, and GIP levels were measured in fasting and postprandial blood samples collected at 15-min intervals for 2 hr. Adjusting for age, body mass index, and gender, the gastric half-emptying time of a glucose meal was significantly (P<0.05) more rapid for the Mexican American subjects (56.5±3.4 min) compared to the non-Hispanic white subjects (66.4±3.5 min). Nondiabetic Mexican Americans empty a liquid glucose meal more rapidly from their stomachs than nondiabetic non-Hispanic whites. Rapid gastric emptying is associated with hyperinsulinemia as a normal physiologic response to increased nutrient availability. The rapid gastric emptying observed in nondiabetic Mexican Americans is associated with hyperinsulinemia and could be a contributing factor for the increased risk of obesity and type II diabetes in this population.
KW - diabetes mellitus
KW - gastric emptying
KW - hyperinsulinemia
KW - Mexican Americans
UR - http://www.scopus.com/inward/record.url?scp=0028901302&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028901302&partnerID=8YFLogxK
U2 - 10.1007/BF02064382
DO - 10.1007/BF02064382
M3 - Article
C2 - 7895557
AN - SCOPUS:0028901302
VL - 40
SP - 624
EP - 630
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
SN - 0163-2116
IS - 3
ER -