TY - CHAP
T1 - Gastric Cancer
T2 - Role of Phytochemicals and Tyrosine Kinase Inhibitors
AU - Khan, Muzammil Muhammad
AU - Sarvepalli, Deepika
AU - Rashid, Mamoon Ur
AU - Zafar, Hammad
AU - Khan, Muhammad Shayan
AU - Zahid, Effa
AU - Khetpal, Akash
AU - Mandzhieva, Bayarmaa
AU - Shobar, Rima
AU - Jalil, Anum
AU - Ahmad, Sarfraz
N1 - Publisher Copyright:
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2020.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Cancer is one of the prominent causes of mortality in the world while carcinoma of stomach happens to be the seventh most prevalent reason for carcinoma-related mortality worldwide. The development of chemotherapeutic drugs has certainly improved cancer patients’ outcomes; however, metastasized cancer remains largely untreatable. Hence, the innovation and research for the effective and safer chemoprevention and treatment of cancers are needed. Cancer chemoprevention and treatments with natural phytochemical compounds is an emerging strategy to potentially cure cancer. For a long time, the study of phytochemicals has shown very encouraging results in clinical trials against cancer cells. Hence, it is recommended that consuming fruits and vegetables by modifying/ improving lifestyle can result in the prevention of different gastrointestinal cancers, including gastric carcinoma. In this chapter, we discuss some of the key natural phytochemicals that exercise their antioxidant properties and also act as inhibitors of inflammation and cancer-causing agents by aiming certain pathways and molecules in gastric carcinoma along with newer targeted therapies of gastric cancer. We also highlight the role of inhibitors of receptor tyrosine kinases in the carcinoma of stomach.
AB - Cancer is one of the prominent causes of mortality in the world while carcinoma of stomach happens to be the seventh most prevalent reason for carcinoma-related mortality worldwide. The development of chemotherapeutic drugs has certainly improved cancer patients’ outcomes; however, metastasized cancer remains largely untreatable. Hence, the innovation and research for the effective and safer chemoprevention and treatment of cancers are needed. Cancer chemoprevention and treatments with natural phytochemical compounds is an emerging strategy to potentially cure cancer. For a long time, the study of phytochemicals has shown very encouraging results in clinical trials against cancer cells. Hence, it is recommended that consuming fruits and vegetables by modifying/ improving lifestyle can result in the prevention of different gastrointestinal cancers, including gastric carcinoma. In this chapter, we discuss some of the key natural phytochemicals that exercise their antioxidant properties and also act as inhibitors of inflammation and cancer-causing agents by aiming certain pathways and molecules in gastric carcinoma along with newer targeted therapies of gastric cancer. We also highlight the role of inhibitors of receptor tyrosine kinases in the carcinoma of stomach.
KW - Anticancer mechanisms
KW - Clinical trials
KW - Gastric carcinoma
KW - Phytochemicals
KW - Tyrosine kinase inhibitors
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U2 - 10.1007/978-3-030-48405-7_9
DO - 10.1007/978-3-030-48405-7_9
M3 - Chapter
AN - SCOPUS:85150118774
SN - 9783030484040
SP - 189
EP - 208
BT - Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers
PB - Springer International Publishing
ER -