Gastric Cancer: Role of Phytochemicals and Tyrosine Kinase Inhibitors

Muzammil Muhammad Khan, Deepika Sarvepalli, Mamoon Ur Rashid, Hammad Zafar, Muhammad Shayan Khan, Effa Zahid, Akash Khetpal, Bayarmaa Mandzhieva, Rima Shobar, Anum Jalil, Sarfraz Ahmad

Research output: Chapter in Book/Report/Conference proceedingChapter


Cancer is one of the prominent causes of mortality in the world while carcinoma of stomach happens to be the seventh most prevalent reason for carcinoma-related mortality worldwide. The development of chemotherapeutic drugs has certainly improved cancer patients’ outcomes; however, metastasized cancer remains largely untreatable. Hence, the innovation and research for the effective and safer chemoprevention and treatment of cancers are needed. Cancer chemoprevention and treatments with natural phytochemical compounds is an emerging strategy to potentially cure cancer. For a long time, the study of phytochemicals has shown very encouraging results in clinical trials against cancer cells. Hence, it is recommended that consuming fruits and vegetables by modifying/ improving lifestyle can result in the prevention of different gastrointestinal cancers, including gastric carcinoma. In this chapter, we discuss some of the key natural phytochemicals that exercise their antioxidant properties and also act as inhibitors of inflammation and cancer-causing agents by aiming certain pathways and molecules in gastric carcinoma along with newer targeted therapies of gastric cancer. We also highlight the role of inhibitors of receptor tyrosine kinases in the carcinoma of stomach.

Original languageEnglish (US)
Title of host publicationPhytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers
PublisherSpringer International Publishing
Number of pages20
ISBN (Electronic)9783030484057
ISBN (Print)9783030484040
StatePublished - Jan 1 2020
Externally publishedYes


  • Anticancer mechanisms
  • Clinical trials
  • Gastric carcinoma
  • Phytochemicals
  • Tyrosine kinase inhibitors

ASJC Scopus subject areas

  • General Medicine


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