Abstract
Superovulation with intrauterine insemination (SO-IUI) has been suggested as an alternative to gamete intrafallopian transfer (GIFT), despite the absence of controlled or comparative trials. We retrospectively analyzed all GIFT and SO-IUI cycles performed concurrently from January 1985 to August of 1987 at a single university center. Pregnancy rates were significantly better for GIFT than SO-IUI (P<0.001), with an odds ratio of 3.25 (P=0.001). Stepwise multiple logistic regression identifield factors that correlate with pregnancy: absence of endometriosis (P=0.05), infertility<3 years' duration (P=0.002), TMS ≧30×106 (P=0.005), and treatment with GIFT rather than SO-IUI (P=0.001). These data give a first approximation of the increased efficacy of GIFT versus SO-IUI and provide valuable insight into significant confounding variables to be considered when planning a randomized, prospective trial to evaluate these techniques.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 298-304 |
| Number of pages | 7 |
| Journal | Journal of in Vitro Fertilization and Embryo Transfer |
| Volume | 6 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1989 |
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Keywords
- gamete intrafallopian transfer (GIFT)
- intrauterine insemination
- superovulation
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology
- Embryology
- Developmental Biology
Cite this
Gamete intrafallopian transfer vs superovulation with intrauterine insemination for the treatment of infertility. / Kaplan, Carolyn R.; Olive, David L.; Sabella, Vincente; Asch, Ricardo H.; Balmaceda, Jose P.; Riehl, Robert M.; Groff, Terry R.; Burns, William N.; Schenken, Robert S.
In: Journal of in Vitro Fertilization and Embryo Transfer, Vol. 6, No. 5, 10.1989, p. 298-304.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gamete intrafallopian transfer vs superovulation with intrauterine insemination for the treatment of infertility
AU - Kaplan, Carolyn R.
AU - Olive, David L.
AU - Sabella, Vincente
AU - Asch, Ricardo H.
AU - Balmaceda, Jose P.
AU - Riehl, Robert M.
AU - Groff, Terry R.
AU - Burns, William N.
AU - Schenken, Robert S
PY - 1989/10
Y1 - 1989/10
N2 - Superovulation with intrauterine insemination (SO-IUI) has been suggested as an alternative to gamete intrafallopian transfer (GIFT), despite the absence of controlled or comparative trials. We retrospectively analyzed all GIFT and SO-IUI cycles performed concurrently from January 1985 to August of 1987 at a single university center. Pregnancy rates were significantly better for GIFT than SO-IUI (P<0.001), with an odds ratio of 3.25 (P=0.001). Stepwise multiple logistic regression identifield factors that correlate with pregnancy: absence of endometriosis (P=0.05), infertility<3 years' duration (P=0.002), TMS ≧30×106 (P=0.005), and treatment with GIFT rather than SO-IUI (P=0.001). These data give a first approximation of the increased efficacy of GIFT versus SO-IUI and provide valuable insight into significant confounding variables to be considered when planning a randomized, prospective trial to evaluate these techniques.
AB - Superovulation with intrauterine insemination (SO-IUI) has been suggested as an alternative to gamete intrafallopian transfer (GIFT), despite the absence of controlled or comparative trials. We retrospectively analyzed all GIFT and SO-IUI cycles performed concurrently from January 1985 to August of 1987 at a single university center. Pregnancy rates were significantly better for GIFT than SO-IUI (P<0.001), with an odds ratio of 3.25 (P=0.001). Stepwise multiple logistic regression identifield factors that correlate with pregnancy: absence of endometriosis (P=0.05), infertility<3 years' duration (P=0.002), TMS ≧30×106 (P=0.005), and treatment with GIFT rather than SO-IUI (P=0.001). These data give a first approximation of the increased efficacy of GIFT versus SO-IUI and provide valuable insight into significant confounding variables to be considered when planning a randomized, prospective trial to evaluate these techniques.
KW - gamete intrafallopian transfer (GIFT)
KW - intrauterine insemination
KW - superovulation
UR - http://www.scopus.com/inward/record.url?scp=0024948703&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024948703&partnerID=8YFLogxK
U2 - 10.1007/BF01139186
DO - 10.1007/BF01139186
M3 - Article
C2 - 2632659
AN - SCOPUS:0024948703
VL - 6
SP - 298
EP - 304
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
SN - 1058-0468
IS - 5
ER -