Gamete intrafallopian transfer vs superovulation with intrauterine insemination for the treatment of infertility

Carolyn R. Kaplan, David L. Olive, Vincente Sabella, Ricardo H. Asch, Jose P. Balmaceda, Robert M. Riehl, Terry R. Groff, William N. Burns, Robert S. Schenken

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Superovulation with intrauterine insemination (SO-IUI) has been suggested as an alternative to gamete intrafallopian transfer (GIFT), despite the absence of controlled or comparative trials. We retrospectively analyzed all GIFT and SO-IUI cycles performed concurrently from January 1985 to August of 1987 at a single university center. Pregnancy rates were significantly better for GIFT than SO-IUI (P<0.001), with an odds ratio of 3.25 (P=0.001). Stepwise multiple logistic regression identifield factors that correlate with pregnancy: absence of endometriosis (P=0.05), infertility<3 years' duration (P=0.002), TMS ≧30×106 (P=0.005), and treatment with GIFT rather than SO-IUI (P=0.001). These data give a first approximation of the increased efficacy of GIFT versus SO-IUI and provide valuable insight into significant confounding variables to be considered when planning a randomized, prospective trial to evaluate these techniques.

Original languageEnglish (US)
Pages (from-to)298-304
Number of pages7
JournalJournal of In Vitro Fertilization and Embryo Transfer
Volume6
Issue number5
DOIs
StatePublished - Oct 1 1989

Keywords

  • gamete intrafallopian transfer (GIFT)
  • intrauterine insemination
  • superovulation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Embryology
  • Obstetrics and Gynecology
  • Developmental Biology

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