Gamete intrafallopian transfer vs superovulation with intrauterine insemination for the treatment of infertility

Carolyn R. Kaplan; David L. Olive; Vincente Sabella; Ricardo H. Asch; Jose P. Balmaceda; Robert M. Riehl; Terry R. Groff; William N. Burns; Robert S. Schenken

doi:10.1007/BF01139186

Gamete intrafallopian transfer vs superovulation with intrauterine insemination for the treatment of infertility

Carolyn R. Kaplan, David L. Olive, Vincente Sabella, Ricardo H. Asch, Jose P. Balmaceda, Robert M. Riehl, Terry R. Groff, William N. Burns, Robert S. Schenken

Obstetrics & Gynecology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Superovulation with intrauterine insemination (SO-IUI) has been suggested as an alternative to gamete intrafallopian transfer (GIFT), despite the absence of controlled or comparative trials. We retrospectively analyzed all GIFT and SO-IUI cycles performed concurrently from January 1985 to August of 1987 at a single university center. Pregnancy rates were significantly better for GIFT than SO-IUI (P<0.001), with an odds ratio of 3.25 (P=0.001). Stepwise multiple logistic regression identifield factors that correlate with pregnancy: absence of endometriosis (P=0.05), infertility<3 years' duration (P=0.002), TMS ≧30×10⁶ (P=0.005), and treatment with GIFT rather than SO-IUI (P=0.001). These data give a first approximation of the increased efficacy of GIFT versus SO-IUI and provide valuable insight into significant confounding variables to be considered when planning a randomized, prospective trial to evaluate these techniques.

Original language	English (US)
Pages (from-to)	298-304
Number of pages	7
Journal	Journal of In Vitro Fertilization and Embryo Transfer
Volume	6
Issue number	5
DOIs	https://doi.org/10.1007/BF01139186
State	Published - Oct 1 1989

Keywords

gamete intrafallopian transfer (GIFT)
intrauterine insemination
superovulation

ASJC Scopus subject areas

Reproductive Medicine
Embryology
Obstetrics and Gynecology
Developmental Biology

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10.1007/BF01139186

Cite this

Gamete intrafallopian transfer vs superovulation with intrauterine insemination for the treatment of infertility. / Kaplan, Carolyn R.; Olive, David L.; Sabella, Vincente; Asch, Ricardo H.; Balmaceda, Jose P.; Riehl, Robert M.; Groff, Terry R.; Burns, William N.; Schenken, Robert S.

In: Journal of In Vitro Fertilization and Embryo Transfer, Vol. 6, No. 5, 01.10.1989, p. 298-304.

Research output: Contribution to journal › Article › peer-review

Kaplan, Carolyn R. ; Olive, David L. ; Sabella, Vincente ; Asch, Ricardo H. ; Balmaceda, Jose P. ; Riehl, Robert M. ; Groff, Terry R. ; Burns, William N. ; Schenken, Robert S. / Gamete intrafallopian transfer vs superovulation with intrauterine insemination for the treatment of infertility. In: Journal of In Vitro Fertilization and Embryo Transfer. 1989 ; Vol. 6, No. 5. pp. 298-304.

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abstract = "Superovulation with intrauterine insemination (SO-IUI) has been suggested as an alternative to gamete intrafallopian transfer (GIFT), despite the absence of controlled or comparative trials. We retrospectively analyzed all GIFT and SO-IUI cycles performed concurrently from January 1985 to August of 1987 at a single university center. Pregnancy rates were significantly better for GIFT than SO-IUI (P<0.001), with an odds ratio of 3.25 (P=0.001). Stepwise multiple logistic regression identifield factors that correlate with pregnancy: absence of endometriosis (P=0.05), infertility<3 years' duration (P=0.002), TMS ≧30×106 (P=0.005), and treatment with GIFT rather than SO-IUI (P=0.001). These data give a first approximation of the increased efficacy of GIFT versus SO-IUI and provide valuable insight into significant confounding variables to be considered when planning a randomized, prospective trial to evaluate these techniques.",

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Gamete intrafallopian transfer vs superovulation with intrauterine insemination for the treatment of infertility

Abstract

Keywords

ASJC Scopus subject areas

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