Abstract
Alpha-feto protein (AFP) is a clinically useful marker for hepatocellular carcinoma, hepatoblastoma, and nonseminomatous testicular tumors. Elevated serum AFP can also occur with tumors of the gastrointestinal tract, pancreas, lung, kidney, and urachus. Serum AFP can also be minimally elevated in nonmalignant conditions including acute and chronic hepatitis, cirrhosis, and pregnancy. Reports of gallbladder carcinoma that elaborate AFP are extremely rare, and almost all represent papillary carcinomas. Until now, there have been only two reports in the world literature that describe undifferentiated gallbladder carcinoma with elevated serum AFP. The authors present one case of undifferentiated gallbladder carcinoma and another case of poorly differentiated gallbladder carcinoma with increased serum AFP. In both cases, serum AFP was particularly useful in documenting metastatic recurrence of gallbladder carcinoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 155-158 |
| Number of pages | 4 |
| Journal | Journal of Clinical Gastroenterology |
| Volume | 28 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1999 |
Fingerprint
Keywords
- AFP tumor marker
- Undifferentiated gallbladder carcinoma
ASJC Scopus subject areas
- Gastroenterology
Cite this
Gallbladder carcinoma producing alpha-fetoprotein. / Laurent, Matthew St; Esterl, Robert M; Halff, Glenn A; Speeg, Kermit V.
In: Journal of Clinical Gastroenterology, Vol. 28, No. 2, 03.1999, p. 155-158.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gallbladder carcinoma producing alpha-fetoprotein
AU - Laurent, Matthew St
AU - Esterl, Robert M
AU - Halff, Glenn A
AU - Speeg, Kermit V
PY - 1999/3
Y1 - 1999/3
N2 - Alpha-feto protein (AFP) is a clinically useful marker for hepatocellular carcinoma, hepatoblastoma, and nonseminomatous testicular tumors. Elevated serum AFP can also occur with tumors of the gastrointestinal tract, pancreas, lung, kidney, and urachus. Serum AFP can also be minimally elevated in nonmalignant conditions including acute and chronic hepatitis, cirrhosis, and pregnancy. Reports of gallbladder carcinoma that elaborate AFP are extremely rare, and almost all represent papillary carcinomas. Until now, there have been only two reports in the world literature that describe undifferentiated gallbladder carcinoma with elevated serum AFP. The authors present one case of undifferentiated gallbladder carcinoma and another case of poorly differentiated gallbladder carcinoma with increased serum AFP. In both cases, serum AFP was particularly useful in documenting metastatic recurrence of gallbladder carcinoma.
AB - Alpha-feto protein (AFP) is a clinically useful marker for hepatocellular carcinoma, hepatoblastoma, and nonseminomatous testicular tumors. Elevated serum AFP can also occur with tumors of the gastrointestinal tract, pancreas, lung, kidney, and urachus. Serum AFP can also be minimally elevated in nonmalignant conditions including acute and chronic hepatitis, cirrhosis, and pregnancy. Reports of gallbladder carcinoma that elaborate AFP are extremely rare, and almost all represent papillary carcinomas. Until now, there have been only two reports in the world literature that describe undifferentiated gallbladder carcinoma with elevated serum AFP. The authors present one case of undifferentiated gallbladder carcinoma and another case of poorly differentiated gallbladder carcinoma with increased serum AFP. In both cases, serum AFP was particularly useful in documenting metastatic recurrence of gallbladder carcinoma.
KW - AFP tumor marker
KW - Undifferentiated gallbladder carcinoma
UR - http://www.scopus.com/inward/record.url?scp=0345130077&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345130077&partnerID=8YFLogxK
U2 - 10.1097/00004836-199903000-00015
DO - 10.1097/00004836-199903000-00015
M3 - Article
C2 - 10078826
AN - SCOPUS:0345130077
VL - 28
SP - 155
EP - 158
JO - Journal of Clinical Gastroenterology
JF - Journal of Clinical Gastroenterology
SN - 0192-0790
IS - 2
ER -